Overview

  • Product name

  • Description

    Rabbit polyclonal to ING1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human ING1 aa 260-353.
    Database link: Q9UK53

  • Positive control

    • WB: Mouse heart tissue lysate. IHC-P: Human glioma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab235091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
WB 1/500 - 1/5000.

Target

  • Function

    Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
  • Tissue specificity

    Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
  • Involvement in disease

    Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
  • Sequence similarities

    Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • 2610028J21Rik antibody
    • AA407184 antibody
    • AI875420 antibody
    • Growth inhibitor ING 1 antibody
    • Growth inhibitor ING1 antibody
    • Growth inhibitory protein ING 1 antibody
    • Growth inhibitory protein ING1 antibody
    • Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds antibody
    • ING 1 antibody
    • Ing1 antibody
    • ING1_HUMAN antibody
    • Inhibitor of growth 1 antibody
    • Inhibitor of growth family member 1 antibody
    • Inhibitor of growth protein 1 antibody
    • mING1h antibody
    • OTTHUMP00000018703 antibody
    • OTTHUMP00000018704 antibody
    • OTTHUMP00000018705 antibody
    • OTTHUMP00000018706 antibody
    • p24ING1c antibody
    • p33 antibody
    • p33 ING1 antibody
    • p33ING1 antibody
    • p33ING1b antibody
    • p33ING1c antibody
    • p37Ing1b antibody
    • p47 antibody
    • p47ING1a antibody
    • Tumor suppressor ING 1 antibody
    • Tumor suppressor ING1 antibody
    see all

Images

  • Paraffin-embedded human glioma tissue stained for ING1 using ab235091 at 1/100 dilution in immunohistochemical analysis.

  • Anti-ING1 antibody (ab235091) at 1/500 dilution + Mouse heart tissue lysate

    Secondary
    Goat polyclonal rabbit IgG at 1/50000 dilution

References

ab235091 has not yet been referenced specifically in any publications.

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