Recombinant
RabMAb

Anti-ING2 antibody [EPR4597-5] (ab174305)

Overview

  • Product name
    Anti-ING2 antibody [EPR4597-5]
    See all ING2 primary antibodies
  • Description
    Rabbit monoclonal [EPR4597-5] to ING2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human ING2. The exact sequence is proprietary.
    Database link: Q9H160

  • Positive control
    • Hela, HT-1080 and Saos-2 cell lysates; Human ING2 recombinant protein.
  • General notes

    Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab174305 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 33 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function
      Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
    • Tissue specificity
      Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
    • Sequence similarities
      Belongs to the ING family.
      Contains 1 PHD-type zinc finger.
    • Domain
      The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
    • Cellular localization
      Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • ING 1 like tumor suppressor protein antibody
      • ING 1L antibody
      • ING 2 antibody
      • ING1 like tumor suppressor protein antibody
      • ING1L antibody
      • ING1Lp antibody
      • ING2 antibody
      • ING2_HUMAN antibody
      • Inhibitor of growth 1 like antibody
      • Inhibitor of growth 1 like protein antibody
      • Inhibitor of growth 1-like protein antibody
      • Inhibitor of growth family member 1 like antibody
      • Inhibitor of growth family member 2 antibody
      • Inhibitor of growth protein 2 antibody
      • p32 antibody
      • p33 ING2 antibody
      • p33ING2 antibody
      see all

    Images

    • All lanes : Anti-ING2 antibody [EPR4597-5] (ab174305) at 1/1000 dilution

      Lane 1 : Hela cell lysate
      Lane 2 : HT-1080 cell lysate
      Lane 3 : Saos-2 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 33 kDa

    • Anti-ING2 antibody [EPR4597-5] (ab174305) at 1/1000 dilution + ING2 recombinant protein (10ng)

      Predicted band size: 33 kDa

    References

    ab174305 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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