Ingenol-3-angelate, PKC activator (ab144280)

Overview

  • Product name

    Ingenol-3-angelate, PKC activator
  • Description

    Specific protein kinase C (PKC) activator.
  • Alternative names

    • PEP 005
  • Biological description

    Selective activator of PKC isoforms, like PKCθ in T cells.
  • Purity

    > 98%
  • CAS Number

    75567-37-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2Z)-2-Methyl-2-butenoic acid (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester
  • Molecular weight

    430.53
  • Molecular formula

    C25H34O6
  • PubChem identifier

    6918670
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C/C=C(/C)\C(=O)O[C@H]1C(=C[C@@]23[C@@]1([C@@H](C(=C[C@H](C2=O)[C@H]4[C@H](C4(C)C)C[C@H]3C)CO)O)O)C
  • Source

    Synthetic

References

This product has been referenced in:

  • Song X  et al. RasGRPs are targets of the anti-cancer agent ingenol-3-angelate. PLoS One 8:e72331 (2013). Read more (PubMed: 23991094) »
  • Lee WY  et al. Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta. J Biol Chem 285:23889-98 (2010). Read more (PubMed: 20472553) »
  • Gillespie SK  et al. Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells. Mol Cancer Ther 3:1651-8 (2004). Read more (PubMed: 15634659) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144280.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up