Overview

  • Product name

  • Description

    Rabbit polyclonal to INPP5E
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human INPP5E.
    Database link: Q9NRR6

  • Positive control

    • HEK293T, sp2/0 and H9C2 whole cell lysates.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab191520 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab191520 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 70 kDa.

Target

  • Function

    Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
  • Tissue specificity

    Detected in brain, heart, pancreas, testis and spleen.
  • Involvement in disease

    Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1) [MIM:213300]. A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease.
    Defects in INPP5E are the cause of mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS) [MIM:610156]. An autosomal recessive disorder characterized by moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males. The phenotype is similar to Bardet-Biedl syndrome and Cohen syndrome Distinguishing features are the age of onset, the non-progressive nature of the visual impairment, lack of dysmorphic facies, skin or gingival infection, microcephaly, mottled retina, polydactyly, and testicular anomalies.
  • Sequence similarities

    Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm > cytoskeleton > cilium axoneme. Golgi apparatus > Golgi stack membrane. Peripheral membrane protein associated with Golgi stacks.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5-bisphosphate 5-phosphatase antibody
    • 72 kDa inositol polyphosphate 5-phosphatase antibody
    • Inositol polyphosphate 5 phosphatase antibody
    • INP5E_HUMAN antibody
    • Inpp5e antibody
    • Phosphatidylinositol (4,5) bisphosphate 5 phosphatase antibody
    • Phosphatidylinositol 4 antibody
    • Phosphatidylinositol polyphosphate 5 phosphatase type IV antibody
    • Phosphatidylinositol polyphosphate 5-phosphatase type IV antibody
    • PPI5PIV antibody
    see all

Images

  • All lanes : Anti-INPP5E antibody (ab191520)

    Lane 1 : HEK293T whole cell lysate
    Lane 2 : sp2/0 whole cell lysate
    Lane 3 : H9C2 whole cell lysate

    Predicted band size: 70 kDa

References

This product has been referenced in:

  • Li KP  et al. Upregulation of miR-598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression. Mol Med Rep 17:2991-2997 (2018). Read more (PubMed: 29257251) »
See 1 Publication for this product

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