Insig1 peptide (ab126817)
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- References
- Protocols
Overview
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Product name
Insig1 peptide
Description
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Nature
Synthetic
Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab126817 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking - Blocking peptide for Anti-Insig1 antibody (ab70784)
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20ºC.
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol, 1% BSA
General Info
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Alternative names
- CL 6
- CL6
- INSI1_HUMAN
see all -
Function
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. -
Tissue specificity
Expressed in all tissues tested with highest expression in the liver. -
Sequence similarities
Belongs to the INSIG family. -
Post-translational
modificationsUbiquitinated. Subsequent to sterol deprivation, the SCAP-SREBF2 complex becomes dissociated from INSIG1, is then ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it is not required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139. -
Cellular localization
Endoplasmic reticulum membrane. - Information by UniProt
References
ab126817 has not yet been referenced specifically in any publications.
