Product nameInsig1 peptide
Our Abpromise guarantee covers the use of ab126817 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Insig1 antibody (ab70784)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol, 1% BSA
- CL 6
FunctionMediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
Tissue specificityExpressed in all tissues tested with highest expression in the liver.
Sequence similaritiesBelongs to the INSIG family.
modificationsUbiquitinated. Subsequent to sterol deprivation, the SCAP-SREBF2 complex becomes dissociated from INSIG1, is then ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it is not required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
ab126817 has not yet been referenced specifically in any publications.