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    insig1-peptide-ab126817.pdf

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Cardiovascular Lipids / Lipoproteins Lipid Metabolism Cholesterol Metabolism
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Insig1 peptide (ab126817)

  • Datasheet
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Key features and details

  • Suitable for: Blocking

Description

  • Product name

    Insig1 peptide
  • Animal free

    No
  • Nature

    Synthetic

Associated products

  • Corresponding Antibody

    • Anti-Insig1 antibody (ab70784)

Specifications

Our Abpromise guarantee covers the use of ab126817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Insig1 antibody (ab70784)

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: PBS, 50% Glycerol, 1% BSA

General Info

  • Alternative names

    • CL 6
    • CL6
    • INSI1_HUMAN
    • INSIG 1
    • INSIG 1 membrane protein
    • INSIG-1
    • insig1
    • INSIG1 membrane protein
    • Insulin induced gene 1
    • Insulin induced gene 1 protein
    • Insulin-induced gene 1 protein
    • MGC1405
    see all
  • Function

    Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
  • Tissue specificity

    Expressed in all tissues tested with highest expression in the liver.
  • Sequence similarities

    Belongs to the INSIG family.
  • Post-translational
    modifications

    Ubiquitinated. Subsequent to sterol deprivation, the SCAP-SREBF2 complex becomes dissociated from INSIG1, is then ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it is not required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Target information above from: UniProt accession O15503 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab126817? Please let us know so that we can cite the reference in this datasheet.

ab126817 has not yet been referenced specifically in any publications.

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