Anti-Insulin antibody (ab7842)

Guinea pig polyclonal Insulin antibody. Validated in IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human, Syrian hamster. Cited in 184 publication(s). Independently reviewed in 29 review(s).

Publishing research using ab7842? Please let us know so that we can cite the reference in this datasheet.

ab7842 has been referenced in 203 publications.

  • Yagishita Y  et al. Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice. J Endocrinol N/A:N/A (2019). PubMed: 30625116
  • Lopez-Pastor AR  et al. Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity. Dis Model Mech 12:N/A (2019). PubMed: 30642871
  • Patel V  et al. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Sci Rep 9:2903 (2019). PubMed: 30814564
  • Pena MJ  et al. Acute effect of an amino acid mixture in the rat glycemic profile. J Cell Biochem N/A:N/A (2019). PubMed: 30873675
  • Yin W  et al. Protein kinase C and protein kinase A are involved in the protection of recombinant human glucagon-like peptide-1 on glomeruli and tubules in diabetic rats. J Diabetes Investig 10:613-625 (2019). PubMed: 30307132
  • Morais T  et al. GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats. J Cell Biochem N/A:N/A (2019). PubMed: 30994953
  • Yuan F  et al. Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic ß Cell Identity in db/db Mice. Evid Based Complement Alternat Med 2019:1232913 (2019). PubMed: 31015847
  • Obata A  et al. Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice. Diabetologia 62:1225-1236 (2019). PubMed: 31055616
  • Wang Y  et al. GPR120 protects lipotoxicity-induced pancreatic ß-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation. Clin Sci (Lond) 133:101-116 (2019). PubMed: 30523046
  • De Leon ER  et al. Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice. Sci Rep 8:17814 (2018). PubMed: 30546031
  • Gatta C  et al. The Case Study of Nesfatin-1 in the Pancreas of Tursiops truncatus. Front Physiol 9:1845 (2018). PubMed: 30618845
  • Page MM  et al. Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain. FASEB J 32:1196-1206 (2018). PubMed: 29122848
  • Amatya C  et al. Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice. Mol Ther 26:184-198 (2018). PubMed: 28988715
  • Jiao A  et al. Simulated Cholinergic Reinnervation of ß (INS-1) Cells: Antidiabetic Utility of Heterotypic Pseudoislets Containing ß Cell and Cholinergic Cell. Int J Endocrinol 2018:1505307 (2018). PubMed: 29755519
  • Ruiz L  et al. Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. Cell Death Dis 9:600 (2018). PubMed: 29789539
  • Yin Y  et al. The homing of human umbilical cord-derived mesenchymal stem cells and the subsequent modulation of macrophage polarization in type 2 diabetic mice. Int Immunopharmacol 60:235-245 (2018). IHC-Fr ; Mouse . PubMed: 29778021
  • Zeng W  et al. Caveolin-1 deficiency protects pancreatic ß cells against palmitate-induced dysfunction and apoptosis. Cell Signal 47:65-78 (2018). IF . PubMed: 29596872
  • Visser CW  et al. In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials. Sci Adv 4:eaao1175 (2018). PubMed: 29399628
  • Katoh MC  et al. MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic a Cells In Vivo. Mol Cell Biol 38:N/A (2018). PubMed: 29378833
  • Yu XX  et al. Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment. Development 145:N/A (2018). PubMed: 29559448
  • Azzarelli R  et al. Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells. Sci Rep 8:15374 (2018). PubMed: 30337647
  • Siniscalco D  et al. Intraperitoneal Administration of Oxygen/Ozone to Rats Reduces the Pancreatic Damage Induced by Streptozotocin. Biology (Basel) 7:N/A (2018). PubMed: 29324687
  • Lee JTC  et al. Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice. Sci Rep 8:4588 (2018). PubMed: 29545618
  • Schofield HK  et al. Pancreatic HIF2a Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol 5:169-185.e2 (2018). PubMed: 29693047
  • Morton KA  et al. Tissue-specific expression and circulating concentrations of nesfatin-1 in domestic animals. Domest Anim Endocrinol 65:56-66 (2018). PubMed: 29909240
  • Miani M  et al. Gut Microbiota-Stimulated Innate Lymphoid Cells Support ß-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes. Cell Metab N/A:N/A (2018). PubMed: 30017352
  • Anzi S  et al. Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals. Dev Cell 45:726-737.e3 (2018). PubMed: 29920277
  • Picke AK  et al. Differential effects of high-fat diet and exercise training on bone and energy metabolism. Bone 116:120-134 (2018). PubMed: 30036679
  • Li Y  et al. Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control. JCI Insight 3:N/A (2018). PubMed: 29769449
  • Grote CW  et al. Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels. Exp Neurol 305:97-107 (2018). IHC-P ; Mouse . PubMed: 29649429
  • Lines KE  et al. A MEN1 pancreatic neuroendocrine tumour mouse model under temporal control. Endocr Connect 6:232-242 (2017). IHC ; Mouse . PubMed: 28420716
  • Alharshawi K  et al. PKC-? is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells. Sci Rep 7:6594 (2017). PubMed: 28747670
  • Juliana CA  et al. ATF5 regulates ß-cell survival during stress. Proc Natl Acad Sci U S A 114:1341-1346 (2017). Mouse . PubMed: 28115692
  • Lees JA  et al. Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Science 355:N/A (2017). PubMed: 28209843
  • Nyalwidhe JO  et al. Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes. PLoS One 12:e0183908 (2017). IHC-P ; Human . PubMed: 28877242
  • Ju L  et al. Salidroside, A Natural Antioxidant, Improves ß-Cell Survival and Function via Activating AMPK Pathway. Front Pharmacol 8:749 (2017). PubMed: 29093682
  • Murao N  et al. Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in ß-cell glutamate signaling for incretin-induced insulin secretion. PLoS One 12:e0187213 (2017). PubMed: 29091932
  • Md Moin AS  et al. Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes. J Endocr Soc 1:385-395 (2017). PubMed: 28782056
  • Harrington S  et al. Improved yield of canine islet isolation from deceased donors. BMC Vet Res 13:264 (2017). PubMed: 28830425
  • Wang H  et al. Augmentation of hypoxia-inducible factor-1-alpha in reinfused blood cells enhances diabetic ischemic wound closure in mice. Oncotarget 8:114251-114258 (2017). PubMed: 29371983
  • Lines KE  et al. Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors. Oncogenesis 6:e332 (2017). IHC-P ; Mouse . PubMed: 28504695
  • Perez-Basterrechea M  et al. Fibroblasts accelerate islet revascularization and improve long-term graft survival in a mouse model of subcutaneous islet transplantation. PLoS One 12:e0180695 (2017). IHC-P ; Mouse . PubMed: 28672010
  • Hatanaka M  et al. Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation. Sci Rep 7:3758 (2017). IF ; Mouse . PubMed: 28630491
  • McKimpson WM  et al. ARC is essential for maintaining pancreatic islet structure and ß-cell viability during type 2 diabetes. Sci Rep 7:7019 (2017). IHC ; Mouse . PubMed: 28765602
  • Wang Y  et al. Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion. Sci Rep 7:779 (2017). PubMed: 28396589
  • Choi JS  et al. Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes. Int J Mol Med 39:1437-1451 (2017). IHC-P ; Mouse . PubMed: 28487991
  • Zhang Y  et al. Differential Effects of Linagliptin on the Function of Human Islets Isolated from Non-diabetic and Diabetic Donors. Sci Rep 7:7964 (2017). PubMed: 28801559
  • Saloustros E  et al. Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis. Endocr Relat Cancer 24:31-40 (2017). PubMed: 27803029
  • Shirakawa J  et al. Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic ß Cell Proliferation. Cell Metab 25:868-882.e5 (2017). PubMed: 28286049
  • García-Sanz P  et al. Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy. Sci Rep 7:389 (2017). PubMed: 28341857
  • Babinsky VN  et al. Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy. Endocrinology 158:2486-2502 (2017). PubMed: 28575322
  • Ida S  et al. Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice. Diabetologia 60:1761-1769 (2017). PubMed: 28642969
  • Rawal S  et al. Integration of mesenchymal stem cells into islet cell spheroids improves long-term viability, but not islet function. Islets 9:87-98 (2017). PubMed: 28662368
  • Ludwig B  et al. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci U S A 114:11745-11750 (2017). PubMed: 29078330
  • Liao HK  et al. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Cell 171:1495-1507.e15 (2017). PubMed: 29224783
  • Muhammad AB  et al. Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB. Am J Physiol Endocrinol Metab 313:E148-E166 (2017). PubMed: 28270438
  • Liu H  et al. Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy 13:1952-1968 (2017). PubMed: 28853981
  • Westacott MJ  et al. Spatially Organized ß-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans. Biophys J 113:1093-1108 (2017). PubMed: 28877492
  • Fan J  et al. cTAGE5 deletion in pancreatic ß cells impairs proinsulin trafficking and insulin biogenesis in mice. J Cell Biol 216:4153-4164 (2017). PubMed: 29133483
  • Gurlo T  et al. CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced ß-Cell Apoptosis. Mol Endocrinol 30:446-54 (2016). PubMed: 26900721
  • Thomas AP  et al. Administration of Melatonin and Metformin Prevents Deleterious Effects of Circadian Disruption and Obesity in Male Rats. Endocrinology 157:4720-4731 (2016). PubMed: 27653034
  • Ocampo A  et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell 167:1719-1733.e12 (2016). PubMed: 27984723
  • O'Hare EA  et al. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of ß-Cell Mass Deficits. Mol Endocrinol 30:429-45 (2016). IHC - Wholemount ; Zebrafish . PubMed: 26963759
  • Vegas AJ  et al. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med 22:306-11 (2016). PubMed: 26808346
  • Molven A  et al. The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice. Diabetes 65:1672-8 (2016). PubMed: 26953163
  • Choudhury SR  et al. In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy. Mol Ther 24:1247-57 (2016). PubMed: 27117222
  • Rabhi N  et al. KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Rep 15:1051-1061 (2016). PubMed: 27117420
  • Michau A  et al. Metabolism Regulates Exposure of Pancreatic Islets to Circulating Molecules In Vivo. Diabetes 65:463-75 (2016). PubMed: 26581596
  • Roth Flach RJ  et al. Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. J Biol Chem 291:16221-30 (2016). IHC-P ; Mouse . PubMed: 27226575
  • Diaz-Castroverde S  et al. Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice. Dis Model Mech 9:1271-1281 (2016). IHC-P ; Mouse . PubMed: 27562101
  • Du W  et al. HID-1 is required for homotypic fusion of immature secretory granules during maturation. Elife 5:N/A (2016). WB, IF ; Mouse . PubMed: 27751232
  • Gurlo T  et al. ß Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity. JCI Insight 1:e89590 (2016). Mouse . PubMed: 27812546
  • Ku SK  et al. Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice. Exp Ther Med 12:354-364 (2016). IHC . PubMed: 27347062
  • Iida A  et al. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Diabetologia 59:1533-41 (2016). IHC-P ; Mouse . PubMed: 27053237
  • Carrasco-Pozo C  et al. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic ß-cells, glycemic control and inflammation: In vitro and in vivo studies. Redox Biol 9:229-243 (2016). PubMed: 27591402
  • Kume S  et al. Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic ? Cells during Fasting and in Type 2 Diabetes. EBioMedicine 13:168-180 (2016). IHC . PubMed: 28005533
  • Abdellatif AM  et al. ß-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One 11:e0150010 (2016). PubMed: 26901059
  • Zha J  et al. Interleukin-1ß-Targeted Vaccine Improves Glucose Control and ß-Cell Function in a Diabetic KK-Ay Mouse Model. PLoS One 11:e0154298 (2016). IHC . PubMed: 27152706
  • Schmidt SF  et al. Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-ROR? Axis Regulating Proliferation in ß Cells. Cell Rep 16:2359-72 (2016). PubMed: 27545881
  • McCommis KS  et al. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Mol Metab 5:602-14 (2016). PubMed: 27656398
  • Beamish CA  et al. Insulin-positive, Glut2-low cells present within mouse pancreas exhibit lineage plasticity and are enriched within extra-islet endocrine cell clusters. Islets 8:65-82 (2016). PubMed: 27010375
  • Yan S  et al. F1F0 ATP Synthase-Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline. Diabetes 65:3482-3494 (2016). PubMed: 27554467
  • Muraro MJ  et al. A Single-Cell Transcriptome Atlas of the Human Pancreas. Cell Syst 3:385-394.e3 (2016). PubMed: 27693023
  • Singhal G  et al. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS One 11:e0148252 (2016). Mouse . PubMed: 26872145
  • Rakshit K  et al. Circadian variation of the pancreatic islet transcriptome. Physiol Genomics 48:677-87 (2016). PubMed: 27495157
  • Huang C  et al. Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets. Int J Mol Med 36:173-85 (2015). IHC-P ; Mouse . PubMed: 25976560
  • Cheung K  et al. CD31 signals confer immune privilege to the vascular endothelium. Proc Natl Acad Sci U S A 112:E5815-24 (2015). IHC-P ; Mouse . PubMed: 26392551
  • Coelho PA  et al. Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse. Open Biol 5:N/A (2015). PubMed: 26701933
  • Razavi R  et al. Diabetes enhances the proliferation of adult pancreatic multipotent progenitor cells and biases their differentiation to more ß-cell production. Diabetes 64:1311-23 (2015). PubMed: 25392245
  • Raum JC  et al. Tshz1 Regulates Pancreatic ß-Cell Maturation. Diabetes 64:2905-14 (2015). Mouse . PubMed: 25918232
  • Tamura K  et al. Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice. PLoS One 10:e0126003 (2015). IHC-P ; Mouse . PubMed: 25938469
  • Johansson U  et al. Pancreatic Islet Survival and Engraftment Is Promoted by Culture on Functionalized Spider Silk Matrices. PLoS One 10:e0130169 (2015). ICC, IHC ; Human . PubMed: 26090859
  • Hoelen H  et al. Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97. PLoS One 10:e0128206 (2015). IP ; Human . PubMed: 26107514
  • Edén D  et al. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets. Diabetologia 58:2563-72 (2015). PubMed: 26271343
  • Chowdhury S  et al. Decreased 11ß-Hydroxysteroid Dehydrogenase 1 Level and Activity in Murine Pancreatic Islets Caused by Insulin-Like Growth Factor I Overexpression. PLoS One 10:e0136656 (2015). PubMed: 26305481
  • Jacovetti C  et al. Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory ß-Cell Mass Expansion. Mol Endocrinol 29:693-702 (2015). PubMed: 25751313
  • Yao DD  et al. Geniposide promotes beta-cell regeneration and survival through regulating ß-catenin/TCF7L2 pathway. Cell Death Dis 6:e1746 (2015). PubMed: 25950476
  • Hagel KR  et al. Drosophila Cbp53E Regulates Axon Growth at the Neuromuscular Junction. PLoS One 10:e0132636 (2015). IHC . PubMed: 26167908
  • Jacovetti C  et al. Postnatal ß-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning. Nat Commun 6:8084 (2015). IHC . PubMed: 26330140
  • Torkko JM  et al. Stability of proICA512/IA-2 and its targeting to insulin secretory granules require ß4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum. Mol Cell Biol 35:914-27 (2015). PubMed: 25561468
  • Wang MY  et al. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. Proc Natl Acad Sci U S A 112:2503-8 (2015). PubMed: 25675519
  • Zhao C  et al. Overcoming Insulin Insufficiency by Forced Follistatin Expression in ß-cells of db/db Mice. Mol Ther 23:866-874 (2015). PubMed: 25676679
  • Kahraman S  et al. Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions. J Diabetes Res 2015:450128 (2015). IF . PubMed: 25699277
  • Sharma RB  et al. Insulin demand regulates ß cell number via the unfolded protein response. J Clin Invest 125:3831-46 (2015). ICC . PubMed: 26389675
  • Chen Y  et al. An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells. Biophys Rep 1:34-40 (2015). PubMed: 26942217
  • Machida Y  et al. Pancreatic islet neuropeptide Y overexpression has minimal effect on islet morphology and ß-cell adaptation to high-fat diet. Endocrinology 155:4634-40 (2014). PubMed: 25285650
  • Aali E  et al. A comparative study of mesenchymal stem cell transplantation with its paracrine effect on control of hyperglycemia in type 1 diabetic rats. J Diabetes Metab Disord 13:76 (2014). IHC . PubMed: 25688339
  • Chowdhury S  et al. IGF-I stimulates CCN5/WISP2 gene expression in pancreatic ß-cells, which promotes cell proliferation and survival against streptozotocin. Endocrinology 155:1629-42 (2014). PubMed: 24552398
  • Naidoo N  et al. Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism. Aging Cell 13:131-41 (2014). PubMed: 24102714
  • Shimoda M  et al. A new method for generating insulin-secreting cells from human pancreatic epithelial cells after islet isolation transformed by NeuroD1. Hum Gene Ther Methods 25:206-19 (2014). PubMed: 24845703
  • Maneva-Radicheva L  et al. Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. PLoS One 9:e107213 (2014). IHC-Fr ; Mouse . PubMed: 25259810
  • Omar BA  et al. Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice. Diabetes 63:101-10 (2014). Mouse . PubMed: 24062250
  • Meyer Zu Schwabedissen HE  et al. OATP1B3 is expressed in pancreatic ß-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide. Diabetes 63:775-84 (2014). Mouse . PubMed: 24150606
  • Fritz JM  et al. Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects. Mol Biol Cell 25:431-40 (2014). IP, IHC-P ; Mouse . PubMed: 24336520
  • Patel MS  et al. Beta cell specific pyruvate dehydrogenase alpha gene deletion results in a reduced islet number and ß-cell mass postnatally. Exp Biol Med (Maywood) N/A:N/A (2014). Mouse . PubMed: 24845368
  • Jaeckle Santos LJ  et al. Neutralizing Th2 inflammation in neonatal islets prevents ß-cell failure in adult IUGR rats. Diabetes 63:1672-84 (2014). PubMed: 24408314
  • Gerdes JM  et al. Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents. Nat Commun 5:5308 (2014). PubMed: 25374274
  • Terami N  et al. Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice. PLoS One 9:e100777 (2014). IHC-P ; Mouse . PubMed: 24960177
  • Espitia Pinzon N  et al. Tissue Transglutaminase in Marmoset Experimental Multiple Sclerosis: Discrepancy between White and Grey Matter. PLoS One 9:e100574 (2014). IHC-P ; Common marmoset . PubMed: 24959868
  • Ohki R  et al. PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors. Proc Natl Acad Sci U S A 111:E2404-13 (2014). PubMed: 24912192
  • Wang R  et al. Perk gene dosage regulates glucose homeostasis by modulating pancreatic ß-cell functions. PLoS One 9:e99684 (2014). IHC ; Mouse . PubMed: 24915520
  • Sauter KA  et al. Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. J Leukoc Biol 96:265-74 (2014). PubMed: 24652541
  • Knoch KP  et al. PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells. Mol Metab 3:518-30 (2014). ICC/IF ; Mouse . PubMed: 25061557
  • Alkanani AK  et al. Kilham rat virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis. Virology 468-470C:19-27 (2014). Rat . PubMed: 25129435
  • Patel M  et al. Non-invasive bioluminescence imaging of ß-cell function in obese-hyperglycemic [ob/ob] mice. PLoS One 9:e106693 (2014). IHC-P ; Mouse . PubMed: 25198535
  • Téllez N & Montanya E Gastrin induces ductal cell dedifferentiation and ß-cell neogenesis after 90% pancreatectomy. J Endocrinol 223:67-78 (2014). PubMed: 25122000
  • Hasegawa Y  et al. Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP recombination. Exp Anim 63:183-91 (2014). PubMed: 24770644
  • Secher A  et al. The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest 124:4473-88 (2014). IHC ; Mouse . PubMed: 25202980
  • Liu X  et al. ß-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory ß-Cell Destruction. Front Endocrinol (Lausanne) 5:165 (2014). IHC ; Mouse . PubMed: 25352830
  • Kuehn C  et al. Young porcine endocrine pancreatic islets cultured in fibrin and alginate gels show improved resistance towards human monocytes. Pathol Biol (Paris) 62:354-64 (2014). PubMed: 25239278
  • Nagasaki H  et al. Generation of insulin-producing cells from the mouse liver using ß cell-related gene transfer including Mafa and Mafb. PLoS One 9:e113022 (2014). IHC ; Mouse . PubMed: 25397325
  • Katsumata T  et al. Bioluminescence imaging of ß cells and intrahepatic insulin gene activity under normal and pathological conditions. PLoS One 8:e60411 (2013). IHC-P ; Mouse . PubMed: 23593212
  • Bramswig NC  et al. Epigenomic plasticity enables human pancreatic a to ß cell reprogramming. J Clin Invest 123:1275-84 (2013). IHC ; Human . PubMed: 23434589
  • Cedervall J  et al. HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment. Angiogenesis 16:889-902 (2013). PubMed: 23793459
  • Gurung B  et al. Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome. Cancer Res 73:2650-8 (2013). PubMed: 23580576
  • Gur C  et al. The expression of the beta cell-derived autoimmune ligand for the killer receptor nkp46 is attenuated in type 2 diabetes. PLoS One 8:e74033 (2013). Electron Microscopy ; Mouse, Gerbil . PubMed: 24009765
  • Suissa Y  et al. Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One 8:e70397 (2013). ICC/IF ; Mouse . PubMed: 23940571
  • Liu Y  et al. Impaired autophagic function in rat islets with aging. Age (Dordr) 35:1531-44 (2013). IHC ; Rat . PubMed: 22843415
  • Schubert U  et al. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone. Proc Natl Acad Sci U S A 110:2288-93 (2013). IHC-Fr . PubMed: 23345449
  • Novikova L  et al. Variations in rodent models of type 1 diabetes: islet morphology. J Diabetes Res 2013:965832 (2013). IHC-P ; Human . PubMed: 23762878
  • Baragli L  et al. Obestatin Enhances In Vitro Generation of Pancreatic Islets through Regulation of Developmental Pathways. PLoS One 8:e64374 (2013). ICC/IF ; Mouse . PubMed: 23741322
  • Schwasinger-Schmidt T  et al. Long-term liraglutide treatment is associated with increased insulin content and secretion in ß-cells, and a loss of a-cells in ZDF rats. Pharmacol Res 76:58-66 (2013). IHC-P ; Rat . PubMed: 23891763
  • Wittig C  et al. Incorporation of bone marrow cells in pancreatic pseudoislets improves posttransplant vascularization and endocrine function. PLoS One 8:e69975 (2013). IHC-P . PubMed: 23875013
  • Wan X  et al. Recovery from overt type 1 diabetes ensues when immune tolerance and ß-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets. Diabetes 62:2879-89 (2013). PubMed: 23715620
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