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ab32216 has been referenced in 36 publications.

  • Kulas JA  et al. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab 316:E106-E120 (2019). PubMed: 30422705
  • Fu W  et al. Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 mice. Exp Ther Med 15:4005-4013 (2018). PubMed: 29563991
  • Khodadadi D  et al. Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels. Neurochem Res 43:1561-1574 (2018). PubMed: 29948724
  • Gao JY  et al. Depressive- and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress. Behav Brain Res 353:114-123 (2018). PubMed: 30012417
  • Wiseman FK  et al. Trisomy of human chromosome 21 enhances amyloid-ß deposition independently of an extra copy of APP. Brain N/A:N/A (2018). PubMed: 29945247
  • Kurauti MA  et al. Interleukin-6 increases the expression and activity of insulin-degrading enzyme. Sci Rep 7:46750 (2017). PubMed: 28429777
  • Vettorazzi JF  et al. Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice. Sci Rep 7:14876 (2017). PubMed: 29093479
  • Lubaczeuski C  et al. Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence. Neural Plast 2017:9652978 (2017). PubMed: 28951790
  • Yang S  et al. Pioglitazone ameliorates Aß42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3ß activation. Mol Med Rep 15:2588-2594 (2017). PubMed: 28447730
  • Huang JZ  et al. Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice. Mol Med Rep 13:491-6 (2016). PubMed: 26531891
  • Son SM  et al. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Autophagy 12:784-800 (2016). PubMed: 26963025
  • Kurauti MA  et al. Acute exercise restores insulin clearance in diet-induced obese mice. J Endocrinol 229:221-32 (2016). PubMed: 27000684
  • Huang H  et al. Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice. Age (Dordr) 38:303-322 (2016). PubMed: 27439903
  • Ries M  et al. The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-ß peptide. J Neuroinflammation 13:234 (2016). PubMed: 27590054
  • Santos RS  et al. Lacking of estradiol reduces insulin exocytosis from pancreatic ß-cells and increases hepatic insulin degradation. Steroids 114:16-24 (2016). WB . PubMed: 27192429
  • Yuan P & Grutzendler J Attenuation of ß-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. J Neurosci 36:632-41 (2016). PubMed: 26758850
  • Sooy K  et al. Cognitive and Disease-Modifying Effects of 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease. Endocrinology 156:4592-603 (2015). WB ; Mouse . PubMed: 26305888
  • Son SM  et al. Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Mol Neurodegener 10:56 (2015). WB . PubMed: 26520569
  • Kukreja L  et al. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol Neurodegener 9:16 (2014). WB . PubMed: 24885175
  • Pedrós I  et al. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Biochim Biophys Acta 1842:1556-66 (2014). WB ; Mouse . PubMed: 24887203
  • Wei X  et al. Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice. PLoS One 9:e95399 (2014). PubMed: 24740421
  • Edrey YH  et al. Oxidative damage and amyloid-ß metabolism in brain regions of the longest-lived rodents. J Neurosci Res 92:195-205 (2014). PubMed: 24273049
  • McCoy DD  et al. Enhanced insulin clearance in mice lacking TRPM8 channels. Am J Physiol Endocrinol Metab 305:E78-88 (2013). PubMed: 23651844
  • Sadleir KR  et al. Elevated Aß42 in aged, non-demented individuals with cerebral atherosclerosis. Curr Alzheimer Res 10:785-9 (2013). PubMed: 23919773
  • Tripathi A  et al. Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification. Biochemistry 52:4184-92 (2013). PubMed: 23697661
  • Sarlus H  et al. Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses. J Neuroinflammation 10:99 (2013). WB ; Mouse . PubMed: 23915208
  • Shingo AS  et al. Cognitive decline in STZ-3V rats is largely due to dysfunctional insulin signalling through the dentate gyrus. Behav Brain Res 229:378-83 (2012). IHC-P ; Rat . PubMed: 22289199
  • Lefort R  et al. Cross-linking of cell surface amyloid precursor protein leads to increased ß-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease. J Neurosci 32:10674-85 (2012). Human . PubMed: 22855816
  • Jayaraman A  et al. 17ß-estradiol and progesterone regulate expression of ß-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology 153:5467-79 (2012). PubMed: 22962256
  • Liu W  et al. Isoflurane-induced spatial memory impairment by a mechanism independent of amyloid-beta levels and tau protein phosphorylation changes in aged rats. Neurol Res 34:3-10 (2012). PubMed: 22196855
  • Sarajärvi T  et al. Bepridil decreases Aß and calcium levels in the thalamus after middle cerebral artery occlusion in rats. J Cell Mol Med 16:2754-67 (2012). WB . PubMed: 22805236
  • Herring A  et al. Exercise during pregnancy mitigates Alzheimer-like pathology in mouse offspring. FASEB J : (2011). WB . PubMed: 21948247
  • Niikura T  et al. A humanin derivative reduces amyloid Beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS One 6:e16259 (2011). IHC-Fr ; Mouse . PubMed: 21264226
  • Griffiths HH  et al. Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein. J Biol Chem 286:33489-500 (2011). WB ; Human . PubMed: 21795680
  • Spilman P  et al. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 5:e9979 (2010). WB ; Mouse . PubMed: 20376313
  • Hiltunen M  et al. Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus. Neurobiol Dis 35:103-13 (2009). PubMed: 19426802


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