Key features and details
- Rabbit polyclonal to Integrin alpha 1 - C-terminal
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
Product nameAnti-Integrin alpha 1 antibody - C-terminal
See all Integrin alpha 1 primary antibodies
DescriptionRabbit polyclonal to Integrin alpha 1 - C-terminal
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Rat, Human
Predicted to work with: Mouse
- Human lung cancer tissue; Human intestinal cancer tissue; rat intestine tissue.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservatives: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab181434 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 130 kDa.|
|IHC-P||Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionIntegrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
Sequence similaritiesBelongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Information by UniProt
- CD 49a antibody
- CD49 antigen-like family member A antibody
- CD49a antibody
All lanes : Anti-Integrin alpha 1 antibody - C-terminal (ab181434) at 0.5 µg/ml
Lane 1 : Rat Brain Tissue Lysate
Lane 2 : HeLa Whole Cell Lysate
Lane 3 : SW620 Whole Cell Lysate
Lysates/proteins at 50 µg per lane.
Predicted band size: 130 kDa
Immunohistochemical analysis of paraffin embedded rat intestine tissue labeling Integrin alpha 1 with ab181434 at 1.0 µg/ml.
Immunohistochemical analysis of paraffin embedded Human intestinal cancer tissue labeling Integrin alpha 1 with ab181434 at 1.0 µg/ml.
Immunohistochemical analysis of paraffin embedded Human lung cancer tissue labeling Integrin alpha 1 with ab181434 at 1.0 µg/ml.
ab181434 has been referenced in 4 publications.
- Melssen MM et al. Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma. Oncoimmunology 7:e1490855 (2018). PubMed: 30288359
- Gharibi A et al. ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer. Sci Rep 7:10060 (2017). PubMed: 28855593
- Yougbaré I et al. Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nat Commun 8:224 (2017). PubMed: 28794456
- Jia D et al. Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin avß3/FAK/AKT Pathway Suppression. Circ Cardiovasc Genet 10:N/A (2017). PubMed: 28077433