Overview

  • Product name

    Anti-Integrin alpha 1 antibody [CL7217]
    See all Integrin alpha 1 primary antibodies
  • Description

    Mouse monoclonal [CL7217] to Integrin alpha 1
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Integrin alpha 1 aa 730-748. The exact sequence is proprietary.
    Sequence:

    RQISRSFFSGTQERKVQRN


    Database link: P56199

  • Positive control

    • IHC-P: Human prostate, placenta and stomach tissue. WB: WM-115 whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab243033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/2500 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 131 kDa.

Target

  • Function

    Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
  • Sequence similarities

    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • Domain

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD 49a antibody
    • CD49 antigen-like family member A antibody
    • CD49a antibody
    • CD49a antigen antibody
    • Integrin alpha-1 antibody
    • ITA1_HUMAN antibody
    • Itga 1 antibody
    • ITGA1 antibody
    • Laminin and collagen receptor antibody
    • Very late activation protein 1 antibody
    • VLA 1 antibody
    • VLA-1 antibody
    • VLA1 antibody
    see all

Images

  • Anti-Integrin alpha 1 antibody [CL7217] (ab243033) at 1 µg/ml + WM-115 whole cell lysate.

    Predicted band size: 131 kDa

  • Paraffin-embedded human stomach tissue stained for Integrin alpha 1 using ab243033 at 1/2500 dilution in immunohistochemical analysis.

  • Paraffin-embedded human placenta tissue stained for Integrin alpha 1 using ab243033 at 1/2500 dilution in immunohistochemical analysis.

  • Paraffin-embedded human prostate tissue stained for Integrin alpha 1 using ab243033 at 1/2500 dilution in immunohistochemical analysis.

  • Negative Control:

    Paraffin-embedded human skeletal muscle tissue stained for Integrin alpha 1 using ab243033 at 1/2500 dilution in immunohistochemical analysis.

References

ab243033 has not yet been referenced specifically in any publications.

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