Anti-Integrin alpha 4+beta 7 antibody [DATK32 (DATK-32)] - Low endotoxin, Azide free (ab171249)

Overview

  • Product name

    Anti-Integrin alpha 4+beta 7 antibody [DATK32 (DATK-32)] - Low endotoxin, Azide free
    See all Integrin alpha 4+beta 7 primary antibodies
  • Description

    Rat monoclonal [DATK32 (DATK-32)] to Integrin alpha 4+beta 7 - Low endotoxin, Azide free
  • Host species

    Rat
  • Tested applications

    Suitable for: Functional Studies, Flow Cytmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control

    • C57Bl/6 splenocytes.
  • General notes

    Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by the LAL assay.

Properties

Applications

Our Abpromise guarantee covers the use of ab171249 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use 1µg for 105-8 cells.

(in a final volume of 100 μl).

ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • Relevance

    Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria.
  • Cellular localization

    Membrane; Single pass type I membrane protein.
  • Database links

  • Alternative names

    • Antigen CD49D antibody
    • CD49d antibody
    • IA4 antibody
    • Integrin alpha 4 subunit antibody
    • Integrin alpha IV antibody
    • Integrin beta 7 antibody
    • Integrin beta 7 subunit antibody
    • ITGA4 antibody
    • ITGB7 antibody
    • LPAM1 antibody
    see all

Images

  • Flow cytometric analysis of C57Bl/6 splenocytes with 0.5 ug of purified Rat IgG2a Isotype control (open histogram) or 0.5 ug of ab171249 (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE. Cells in the lymphocyte gate were used for analysis.

References

ab171249 has not yet been referenced specifically in any publications.

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