Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2] (ab97588)
Key features and details
- Rat monoclonal [avB6 53a.2] to Integrin alpha V + beta 6
- Suitable for: ICC/IF, Neutralising, Flow Cyt
- Reacts with: Human
- Isotype: IgG2a
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2]
See all Integrin alpha V + beta 6 primary antibodies -
Description
Rat monoclonal [avB6 53a.2] to Integrin alpha V + beta 6 -
Host species
Rat -
Tested applications
Suitable for: ICC/IF, Neutralising, Flow Cytmore details -
Species reactivity
Reacts with: Human -
Immunogen
Full length protein corresponding to Integrin alpha V + beta 6. Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.
Database link: P06756 -
Epitope
Extracelllular region of the heterodimer. -
Positive control
- BT20 breast carcinoma, original immunogen.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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Purity
Protein A/G purified -
Clonality
Monoclonal -
Clone number
avB6 53a.2 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab97588 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ICC/IF |
Use at an assay dependent concentration.
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Neutralising |
Use at an assay dependent concentration.
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Flow Cyt | (1) |
Use at an assay dependent concentration.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Notes |
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ICC/IF
Use at an assay dependent concentration. |
Neutralising
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Target
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Function
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. -
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3685 Human
- Entrez Gene: 3694 Human
- Omim: 147558 Human
- Omim: 193210 Human
- SwissProt: P06756 Human
- SwissProt: P18564 Human
- Unigene: 436873 Human
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Alternative names
- CD51 antibody
- Integrin alpha-V light chain antibody
- integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab97588 has been referenced in 6 publications.
- Schiesser JV et al. Integrin avß5 heterodimer is a specific marker of human pancreatic beta cells. Sci Rep 11:8315 (2021). PubMed: 33859325
- Ran R et al. A role for CBFß in maintaining the metastatic phenotype of breast cancer cells. Oncogene 39:2624-2637 (2020). PubMed: 32005976
- Liu H et al. IL-32? promotes integrin avß6 expression through the activation of NF-?B in HSCs. Exp Ther Med 14:3880-3886 (2017). PubMed: 29042996
- Coughlan L et al. Combined fiber modifications both to target a(v)ß(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5. Hum Gene Ther 23:960-79 (2012). Flow Cyt ; Human . PubMed: 22708837
- Marsh D et al. alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. Cancer Res 68:3295-303 (2008). PubMed: 18451156
- Myou S et al. Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2. Immunology 107:77-85 (2002). PubMed: 12225365