Anti-Integrin alpha V antibody [RMV-7] (ab63490)
Key features and details
- Rat monoclonal [RMV-7] to Integrin alpha V
- Suitable for: IP, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG1
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Integrin alpha V antibody [RMV-7]
See all Integrin alpha V primary antibodies -
Description
Rat monoclonal [RMV-7] to Integrin alpha V -
Host species
Rat -
Tested applications
Suitable for: IP, Flow Cytmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Tissue, cells or virus corresponding to Mouse Integrin alpha V. Cultured LAK cells from Balb/c mice
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant. -
Clonality
Monoclonal -
Clone number
RMV-7 -
Myeloma
P3x63-Ag8.653 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab63490 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IP |
Use at an assay dependent concentration.
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Flow Cyt |
1/10 - 1/100.
ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10 µl of the suggested working dilution to label 106 cells in 100µl. |
Notes |
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IP
Use at an assay dependent concentration. |
Flow Cyt
1/10 - 1/100. ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10 µl of the suggested working dilution to label 106 cells in 100µl. |
Target
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Function
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. -
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 16410 Mouse
- SwissProt: P43406 Mouse
- Unigene: 227 Mouse
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Alternative names
- antigen identified by monoclonal antibody L230 antibody
- CD 51 antibody
- CD51 antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (2)
ab63490 has been referenced in 2 publications.
- Khalifeh-Soltani A et al. Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med 20:175-83 (2014). PubMed: 24441829
- Gupton SL et al. Mena binds a5 integrin directly and modulates a5ß1 function. J Cell Biol 198:657-76 (2012). IF . PubMed: 22908313