Overview

  • Product name

    Anti-Integrin alpha V beta 3 antibody [23C6] (Biotin)
    See all Integrin alpha V beta 3 primary antibodies
  • Description

    Mouse monoclonal [23C6] to Integrin alpha V beta 3 (Biotin)
  • Host species

    Mouse
  • Conjugation

    Biotin
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control

    • M21 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab134488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 1µg for 105-8 cells.

ab18434 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • Relevance

    Function: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C (PubMed:20615244). Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1 (PubMed:9426447, PubMed:15194773, PubMed:7519807). Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 (PubMed:24367260). Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for West nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733). Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats.
  • Cellular localization

    Cell Membrane. Cytoplasmic. Integrin complex. Focal adhesion.
  • Database links

  • Alternative names

    • Antigen identified by monoclonal antibody L230 antibody
    • CD 51 antibody
    • CD 61 antibody
    • CD51 antibody
    • CD51 antigen antibody
    • CD61 antibody
    • CD61 antigen antibody
    • DKFZp686A08142 antibody
    • GP3A antibody
    • GPIIIa antibody
    • Integrin alpha V antibody
    • Integrin alpha V vitronectin receptor alpha polypeptide antibody
    • Integrin alpha V vitronectin receptor alpha polypeptide antigen CD51 antibody
    • integrin alpha-V antibody
    • Integrin alpha-V light chain antibody
    • Integrin beta 3 antibody
    • Integrin beta 3 platelet glycoprotein IIIa antigen CD61 antibody
    • Integrin beta chain beta 3 antibody
    • integrinVbeta3 antibody
    • ITAV_HUMAN antibody
    • ITGAV antibody
    • ITGB 3 antibody
    • ITGB3 antibody
    • MSK 8 antibody
    • MSK8 antibody
    • Platelet glycoprotein IIIa antibody
    • Platelet glycoprotein IIIa precursor antibody
    • Platelet membrane glycoprotein IIIa antibody
    • Vitronectin receptor alpha polypeptide antibody
    • vitronectin receptor antibody
    • Vitronectin receptor subunit alpha antibody
    • VNR 1 antibody
    • VNR1 antibody
    • VNRA antibody
    see all

Images

  • Flow cytometric analysis of total viable M21 cells labelling Integrin alpha V beta 3 with ab134488 (filled histogram) at 0.5 µg or with 0.5 µg of Mouse IgG1 kappa Isotype Control (open histogram), followed by Streptavidin PE.

References

ab134488 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab134488.
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