Overview

  • Product name

    Anti-Integrin beta 7 antibody
    See all Integrin beta 7 primary antibodies
  • Description

    Rabbit polyclonal to Integrin beta 7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Integrin beta 7. (Near the N terminal; NP_000880).
    Database link: P26010

  • Positive control

    • PC3 and K562 cell lysates. Human gastric cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab198796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 87 kDa.

Target

  • Function

    Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
  • Tissue specificity

    Expressed in a variety of leukocyte lines.
  • Sequence similarities

    Belongs to the integrin beta chain family.
    Contains 1 VWFA domain.
  • Domain

    Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Gut homing receptor beta subunit antibody
    • Integrin beta 7 subunit antibody
    • Integrin beta-7 antibody
    • Integrin beta-P antibody
    • Integrin, beta 7 antibody
    • ITB7 antibody
    • ITB7_HUMAN antibody
    • Itgb7 antibody
    • Ly69 antibody
    • M290 IEL antigen antibody
    see all

Images

  • All lanes : Anti-Integrin beta 7 antibody (ab198796) at 1/200 dilution

    Lane 1 : PC3 cell lysate
    Lane 2 : K562 cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 87 kDa


    Exposure time: 10 minutes


    Gel: 6% SDS-PAGE.

  • Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling Integrin beta 7 with ab198796 at 1/30 dilution.

References

ab198796 has not yet been referenced specifically in any publications.

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