Anti-Interferon alpha/beta receptor 1 antibody (ab175452)
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Overview
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Product nameAnti-Interferon alpha/beta receptor 1 antibody
See all Interferon alpha/beta receptor 1 primary antibodies -
DescriptionGoat polyclonal to Interferon alpha/beta receptor 1
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Host speciesGoat
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Human
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Immunogen
Synthetic peptide corresponding to Human Interferon alpha/beta receptor 1 aa 353-364 (internal sequence) (Cysteine residue). NP_000620.2.
Sequence:PKQSGNTPVIQD
Database link: P17181 -
Positive control
- K562 lysates
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
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Storage bufferpH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 99% Tris buffered saline -
Concentration information loading... -
PurityImmunogen affinity purified
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Purification notesab175452 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Related Products
Applications
Our Abpromise guarantee covers the use of ab175452 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 64 kDa. |
Target
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FunctionAssociates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
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Tissue specificityIFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
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Sequence similaritiesBelongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains. -
Post-translational
modificationsPhosphorylated on tyrosine residues by TYK2 tyrosine kinase. -
Cellular localizationMembrane.
- Information by UniProt
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Database links
- Entrez Gene: 3454 Human
- Omim: 107450 Human
- SwissProt: P17181 Human
- Unigene: 529400 Human
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Alternative names
- Alpha type antiviral protein antibody
- Antiviral protein, alpha-type antibody
- Antiviral protein, beta-type antibody
see all
Images
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Western blot - Anti-Interferon alpha/beta receptor 1 antibody (ab175452)Anti-Interferon alpha/beta receptor 1 antibody (ab175452) at 0.3 µg/ml + K562 lysates at 35 µg
Predicted band size: 64 kDaPrimary incubation was 1 hour. Detected by chemiluminescence.
Datasheets and documents
Protocols
References
ab175452 has not yet been referenced specifically in any publications.
