Overview

  • Product name

    Anti-Interferon alpha/beta receptor 1 antibody
    See all Interferon alpha/beta receptor 1 primary antibodies
  • Description

    Rabbit polyclonal to Interferon alpha/beta receptor 1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Interferon alpha/beta receptor 1 aa 28-290.
    Sequence:

    KNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ


    Database link: P17181

  • Positive control

    • HeLa, HepG2 and SW480 cell line extracts

Properties

Applications

Our Abpromise guarantee covers the use of ab180812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

WB 1/500 - 1/2000. Predicted molecular weight: 64 kDa.

Target

  • Function

    Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
  • Tissue specificity

    IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
  • Sequence similarities

    Belongs to the type II cytokine receptor family.
    Contains 3 fibronectin type-III domains.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Alpha type antiviral protein antibody
    • Antiviral protein, alpha-type antibody
    • Antiviral protein, beta-type antibody
    • AVP antibody
    • Beta type antiviral protein antibody
    • CRF2-1 antibody
    • Cytokine receptor class-II member 1 antibody
    • Cytokine receptor family 2 member 1 antibody
    • IFN alpha REC antibody
    • IFN alpha receptor antibody
    • IFN alpha/beta Receptor alpha antibody
    • IFN beta receptor antibody
    • IFN Interferon-beta receptor antibody
    • IFN-alpha/beta receptor 1 antibody
    • IFN-R-1 antibody
    • IFNAR antibody
    • Ifnar1 antibody
    • IFNBR antibody
    • IFRC antibody
    • INAR1_HUMAN antibody
    • Interferon (alpha beta and omega) receptor 1 antibody
    • interferon alpha and beta receptor subunit 1 antibody
    • Interferon alpha/beta receptor 1 antibody
    • Interferon alpha/beta receptor alpha chain antibody
    • Interferon beta receptor 1 antibody
    • interferon receptor 1 antibody
    • Interferon-alpha receptor antibody
    • Type I interferon receptor 1 antibody
    see all

Images

  • All lanes : Anti-Interferon alpha/beta receptor 1 antibody (ab180812) at 1/500 dilution

    Lane 1 : HeLa cell line extracts
    Lane 2 : HepG2 cell line extracts
    Lane 3 : SW480 cell line extracts

    Predicted band size: 64 kDa

References

This product has been referenced in:

  • Chang LC  et al. The Protein Expression of PDL1 Is Highly Correlated with Those of eIF2a and ATF4 in Lung Cancer. Dis Markers 2018:5068701 (2018). Read more (PubMed: 30305853) »
See 1 Publication for this product

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