Overview

  • Product name

    Anti-Interferon alpha/beta receptor 1 antibody
    See all Interferon alpha/beta receptor 1 primary antibodies
  • Description

    Rabbit polyclonal to Interferon alpha/beta receptor 1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Interferon alpha/beta receptor 1 aa 507-557. The exact sequence is proprietary. NP_000620.2
    Database link: P17181

  • Positive control

    • WB: HeLa, HEK-293T and Jurkat whole cell lysates. IP: HEK-293T whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab245367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 64 kDa.
IP Use at 2-10 µg/mg of lysate.

Target

  • Function

    Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
  • Tissue specificity

    IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
  • Sequence similarities

    Belongs to the type II cytokine receptor family.
    Contains 3 fibronectin type-III domains.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Alpha type antiviral protein antibody
    • Antiviral protein, alpha-type antibody
    • Antiviral protein, beta-type antibody
    • AVP antibody
    • Beta type antiviral protein antibody
    • CRF2-1 antibody
    • Cytokine receptor class-II member 1 antibody
    • Cytokine receptor family 2 member 1 antibody
    • IFN alpha REC antibody
    • IFN alpha receptor antibody
    • IFN alpha/beta Receptor alpha antibody
    • IFN beta receptor antibody
    • IFN Interferon-beta receptor antibody
    • IFN-alpha/beta receptor 1 antibody
    • IFN-R-1 antibody
    • IFNAR antibody
    • Ifnar1 antibody
    • IFNBR antibody
    • IFRC antibody
    • INAR1_HUMAN antibody
    • Interferon (alpha beta and omega) receptor 1 antibody
    • interferon alpha and beta receptor subunit 1 antibody
    • Interferon alpha/beta receptor 1 antibody
    • Interferon alpha/beta receptor alpha chain antibody
    • Interferon beta receptor 1 antibody
    • interferon receptor 1 antibody
    • Interferon-alpha receptor antibody
    • Type I interferon receptor 1 antibody
    see all

Images

  • All lanes : Anti-Interferon alpha/beta receptor 1 antibody (ab245367) at 0.4 µg/ml

    Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
    Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
    Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

    Lysates/proteins at 50 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 64 kDa


    Exposure time: 30 seconds
  • Interferon alpha/beta receptor 1 was immunoprecipitated from HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab245367 at 6 µg/mg lysate. Western blot was performed from the immunoprecipitate using ab245367 at 1 µg/ml.

    Lane 1: ab245367 IP in HEK-293T whole cell lysate.
    Lane 2: Control IgG IP in HEK-293T whole cell lysate.

    Detection: Chemiluminescence with exposure time of 30 seconds.

References

ab245367 has not yet been referenced specifically in any publications.

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