Anti-Interferon alpha/beta receptor 1 (phospho S535 + S539) antibody (ab30571)
Key features and details
- Rabbit polyclonal to Interferon alpha/beta receptor 1 (phospho S535 + S539)
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Interferon alpha/beta receptor 1 (phospho S535 + S539) antibody
See all Interferon alpha/beta receptor 1 primary antibodies -
Description
Rabbit polyclonal to Interferon alpha/beta receptor 1 (phospho S535 + S539) -
Host species
Rabbit -
Specificity
Specific for Interferon alpha/beta receptor 1 protein phosphorylated at Ser535,539 in Western blots of human brain extracts. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human Interferon alpha/beta receptor 1 (phospho S535 + S539).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.50
Constituents: 0.238% HEPES, 50% Glycerol, 0.87% Sodium chloride, 0.01% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho-and dephosphopeptide affinity columns. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab30571 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000. Predicted molecular weight: 110-130 kDa.
Note: the molecular weight of the IFNNAR1 varies with cell line (different levels of glycosylation) in 293 and HeLa Cells; the mature form is ~110 - 130k. |
Notes |
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WB
1/1000. Predicted molecular weight: 110-130 kDa. Note: the molecular weight of the IFNNAR1 varies with cell line (different levels of glycosylation) in 293 and HeLa Cells; the mature form is ~110 - 130k. |
Target
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Function
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. -
Tissue specificity
IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. -
Sequence similarities
Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains. -
Post-translational
modificationsPhosphorylated on tyrosine residues by TYK2 tyrosine kinase. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3454 Human
- Omim: 107450 Human
- SwissProt: P17181 Human
- Unigene: 529400 Human
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Alternative names
- Alpha type antiviral protein antibody
- Antiviral protein, alpha-type antibody
- Antiviral protein, beta-type antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab30571 has not yet been referenced specifically in any publications.