Anti-Interferon gamma antibody (ab7740)

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Key features and details

  • Rabbit polyclonal to Interferon gamma
  • Suitable for: IHC-Fr, Inhibition Assay, WB, Neutralising
  • Reacts with: Rat
  • Isotype: IgG

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Anti-Interferon gamma antibody [EPR21704] (ab231036)
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  • Success from the first experiment – confirmed specificity through extensive validation
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Overview

  • Product name

    Anti-Interferon gamma antibody
    See all Interferon gamma primary antibodies

  • Description

    Rabbit polyclonal to Interferon gamma

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-Fr, Inhibition Assay, WB, Neutralisingmore details

  • Species reactivity

    Reacts with: Rat

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab7740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr
Use at an assay dependent concentration.
Inhibition Assay
Use at an assay dependent concentration.
WB
Use at an assay dependent concentration.
Neutralising
Use at an assay dependent concentration.
Notes
IHC-Fr
Use at an assay dependent concentration.
Inhibition Assay
Use at an assay dependent concentration.
WB
Use at an assay dependent concentration.
Neutralising
Use at an assay dependent concentration.

Target

  • Function

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

  • Tissue specificity

    Released primarily from activated T lymphocytes.

  • Involvement in disease

    In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.

  • Sequence similarities

    Belongs to the type II (or gamma) interferon family.

  • Post-translational
    modifications

    Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • IF 1 antibody
      • IFG antibody
      • IFI antibody
      • ifn g antibody
      • IFN gamma antibody
      • IFN immune antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      • Type II Interferon antibody
      see all

    References (2)

    Publishing research using ab7740? Please let us know so that we can cite the reference in this datasheet.

    ab7740 has been referenced in 2 publications.

    • Guan L  et al. PM2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids. Oncotarget 9:3765-3778 (2018). PubMed: 29423081
    • Luo S  et al. Effect of nutritional supplement on bone marrow-derived mesenchymal stem cells from aplastic anaemia. Br J Nutr 119:748-758 (2018). PubMed: 29569543

    Customer reviews and Q&As

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