Anti-Interferon gamma antibody (ab9918)
Key features and details
- Rabbit polyclonal to Interferon gamma
- Reacts with: Mouse
- Isotype: unknown
Overview
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Product name
Anti-Interferon gamma antibody
See all Interferon gamma primary antibodies -
Description
Rabbit polyclonal to Interferon gamma -
Host species
Rabbit -
Species reactivity
Reacts with: Mouse -
Immunogen
Highly pure (>98%) recombinant mIFN-g (mouse Interferon-gamma).
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Positive control
- Recombinant mouse Interferon gamma protein (ab9922) can be used as a positive control in WB.
Properties
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Form
Lyophilized:Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
No preservative, sterile filtered -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
unknown -
Light chain type
unknown -
Research areas
Associated products
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Positive Controls
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Recombinant Protein
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sELISA pair antibody
Target
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Function
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. -
Tissue specificity
Released primarily from activated T lymphocytes. -
Involvement in disease
In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis. -
Sequence similarities
Belongs to the type II (or gamma) interferon family. -
Post-translational
modificationsProteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 15978 Mouse
- SwissProt: P01580 Mouse
- Unigene: 240327 Mouse
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Alternative names
- IF 1 antibody
- IFG antibody
- IFI antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab9918 has been referenced in 2 publications.
- Zheng C et al. Low-intensity pulsed ultrasound attenuates cardiac inflammation of CVB3-induced viral myocarditis via regulation of caveolin-1 and MAPK pathways. J Cell Mol Med 23:1963-1975 (2019). PubMed: 30592150
- Mastronardi FG et al. Synergy between paclitaxel plus an exogenous methyl donor in the suppression of murine demyelinating diseases. Mult Scler 13:596-609 (2007). PubMed: 17548438