Overview

  • Product name
    Anti-Interferon gamma antibody [B-B1]
    See all Interferon gamma primary antibodies
  • Description
    Mouse monoclonal [B-B1] to Interferon gamma
  • Host species
    Mouse
  • Specificity
    ab47343 recognises both natural and recombinant Human Interferon gamma.
  • Tested applications
    Suitable for: Blocking, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human Interferon gamma.

Properties

Applications

Our Abpromise guarantee covers the use of ab47343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Blocking
Flow Cyt
  • Application notes
    BL: Use at an assay dependent dilution.
    note: ab47343 blocks Interferon gamma-induced proliferation.
    Flow Cyt: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • Tissue specificity
      Released primarily from activated T lymphocytes.
    • Involvement in disease
      In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • Sequence similarities
      Belongs to the type II (or gamma) interferon family.
    • Post-translational
      modifications
      Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    References

    ab47343 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Answer

    Thank you for contacting us with your enquiry, and for your patience while I have been in contact with the lab to request more information.

    We do not have any in-house data for this antibody in blocking assays, but I have attached a reference that the lab sent to me. This is the only interferon gamma antibody known to work in a blocking assay thatwe havein an azide-free format.

    I hope this information will be useful, but please let me know if you have any further questions or if there is anything else that we can do for you, and I'll be happy to help.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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