Key features and details
- Rabbit polyclonal to Interferon gamma (Biotin)
- Suitable for: ELISA, WB
- Reacts with: Horse, Cow, Cat, Dog, Human, Pig, Dolphin
- Conjugation: Biotin
- Isotype: IgG
Product nameAnti-Interferon gamma antibody (Biotin)
See all Interferon gamma primary antibodies
DescriptionRabbit polyclonal to Interferon gamma (Biotin)
Tested applicationsSuitable for: ELISA, WBmore details
Species reactivityReacts with: Horse, Cow, Cat, Dog, Human, Pig, Dolphin
Predicted to work with: Mouse, RabbitDoes not react with: Chicken
Recombinant fragment within Equus Interferon gamma aa 21-166. The exact sequence is proprietary.
YYCQAAFFKE IENLKEYFNA SNPDVGDGGP LFLDILKNWK EDSDKKIIQS QIVSFYFKLF ENLKDNQVIQ KSMDTIKEDL FAKFFNSSTS KLEDFQKLIQ IPVNDLKVQR KAISELIKVM NDLSPKANLR KRKRSQNPFR GRRALQ
Database link: P42160
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab193846 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use a concentration of 0.1 - 1 µg/ml.|
|WB||Use a concentration of 0.1 - 1 µg/ml. Predicted molecular weight: 17 kDa.|
FunctionProduced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Tissue specificityReleased primarily from activated T lymphocytes.
Involvement in diseaseIn Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
Sequence similaritiesBelongs to the type II (or gamma) interferon family.
modificationsProteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
- Information by UniProt
- IF 1 antibody
- IFG antibody
- IFI antibody
ab193846 has not yet been referenced specifically in any publications.