Overview

  • Product name

    Anti-Interferon gamma antibody [F1]
    See all Interferon gamma primary antibodies
  • Description

    Rat monoclonal [F1] to Interferon gamma
  • Host species

    Rat
  • Tested applications

    Suitable for: Purification, IPmore details
    Unsuitable for: Neut
  • Species reactivity

    Reacts with: Mouse
    Does not react with: Rat, Human
  • Immunogen

    Recombinant full length protein (Mouse).

  • General notes

    Possible applications include the purification of human gamma interferon. In general, monoclonal antibodies to gamma interferon are able to inhibit Shwartzman reactions and in the murine system appear to protect NZB mice against spontaneous development of autoimmune disease.

Properties

Applications

Our Abpromise guarantee covers the use of ab11855 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Purification Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
  • Application notes
    Is unsuitable for Neut.
  • Target

    • Function

      Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • Tissue specificity

      Released primarily from activated T lymphocytes.
    • Involvement in disease

      In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • Sequence similarities

      Belongs to the type II (or gamma) interferon family.
    • Post-translational
      modifications

      Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • Cellular localization

      Secreted.
    • Information by UniProt
    • Database links

    • Alternative names

      • IF 1 antibody
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN immune antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      • Type II Interferon antibody
      see all

    References

    ab11855 has not yet been referenced specifically in any publications.

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