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Rabbit polyclonal to Intersectin 1
Predicted to work with:
Recombinant fragment, corresponding to amino acids 646-840 of Human Intersectin 1 (BC116186).
Lyophilised:Reconstitute in 200µl Steriled Distilled Water
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.02% Sodium azide Constituents: 98% PBS, 1% BSA
Concentration information loading...
Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Predicted molecular weight: 195 kDa.
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord.
Contains 1 C2 domain.
Contains 1 DH (DBL-homology) domain. Contains 2 EF-hand domains. Contains 2 EH domains. Contains 1 PH domain. Contains 5 SH3 domains.
SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31.
The KLERQ domain binds to SNAP-25 and SNAP-23.
Endomembrane system. Cell junction > synapse > synaptosome. Cell projection > lamellipodium.
Information by UniProt
Human intersectin SH3 domain containing protein SH3P17 antibody
Intersectin 1 SH3 domain protein antibody
intersectin 1 short form variant 3 antibody
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