Overview

  • Product name

    Anti-INTS6 antibody
  • Description

    Rabbit polyclonal to INTS6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IP, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Opossum, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to Human INTS6.

  • General notes

    Previously labelled as DDX26.

Properties

Applications

Our Abpromise guarantee covers the use of ab86369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 100 kDa.
IP Use a concentration of 2 - 5 µg/ml.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.
  • Tissue specificity

    Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Sequence similarities

    Belongs to the Integrator subunit 6 family.
    Contains 1 VWFA domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • DBI 1 antibody
    • DBI-1 antibody
    • DBI1 antibody
    • DDX26 antibody
    • DDX26A antibody
    • DEAD box protein antibody
    • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26 antibody
    • Deleted in cancer 1 antibody
    • DICE1 antibody
    • DKFZp434B105 antibody
    • HDB antibody
    • Int6 antibody
    • INT6_HUMAN antibody
    • Integrator complex subunit 6 antibody
    • INTS 6 antibody
    • ints6 antibody
    • Notchl2 antibody
    • OTTHUMP00000018439 antibody
    • OTTHUMP00000215034 antibody
    • OTTHUMP00000215036 antibody
    • Protein DDX26 antibody
    • Protein deleted in cancer 1 antibody
    • RNA helicase HDB antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid carcinoma tissue labelling INTS6 with ab86369 at 1/200 (1µg/ml). Detection: DAB.

  • All lanes : Anti-INTS6 antibody (ab86369) at 0.04 µg/ml

    Lane 1 : Whole cell lysate from HeLa cells at 50 µg
    Lane 2 : Whole cell lysate from HeLa cells at 15 µg
    Lane 3 : Whole cell lysate from HeLa cells at 5 µg

    Predicted band size: 100 kDa
    Observed band size: 117 kDa
    why is the actual band size different from the predicted?

References

ab86369 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab86369.
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