Overview

  • Product name
    Ionotropic Agonists Kit
  • Specificity
    A collection of 8 agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of solvent provides a stock solution of 5 mM or 10 mM, respectively. The kit contains (S)-AMPA, (ab120005), (S)-5-Fluorowillardiine hydrochloride (ab120399), Cyclothiazide (ab120061), Aniracetam (ab120316), Kainic acid (ab120100), (S)-5-Iodowillardiine hydrochloride (ab120401), NMDA (ab120052) and D-serine (ab120048).
  • Product overview

    A collection of 8 agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of solvent provides a stock solution of 5 mM or 10 mM, respectively. The kit contains (S)-AMPA, (ab120005), (S)-5-Fluorowillardiine hydrochloride (ab120399), Cyclothiazide (ab120061), Aniracetam (ab120316), Kainic acid (ab120100), (S)-5-Iodowillardiine hydrochloride (ab120401) , NMDA ab120052) and D-serine (ab120048). 


    Receptor


    Description 


    AMPA 


    (S)-AMPA:  


    AMPA agonist. 


    Suggested Solvent: Water 


    AMPA 


    Cyclothiazide:  


    Positive allosteric modulator of AMPA receptors. Produces a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. 


    Suggested Solvent: DMSO 


    AMPA


    Aniracetam:  


    Nootropic, positive allosteric modulator of AMPA receptors. Slows AMPA receptor deactivation and desensitisation. Antidepressant and anxiolytic in vivo


    Suggested Solvent: DMSO 


    Kainate 


    Kainic acid:  


    Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states. 


    Suggested Solvent: Water 


    Kainate 


    NMDA:  


    Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy. 


    Suggested Solvent: Water 


    NMDA 


    D-Serine:  


    Agonist at the NMDA glycine binding site and the inhibitory post-synaptic glycine receptor. 


    Suggested Solvent: Water 

  • Notes

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    KIT

Properties

References

ab120323 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Question
Answer

Thank you for contacting us.

These products are freeze dried to an exact weight so adding 0.5 ml in each product will give you conc. of 10 mM.

0.5 ml addition of water or solvent into each product will give 10 mM solution.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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