Anti-Ionotropic Glutamate receptor 4 antibody (ab171423)

Overview

  • Product name
    Anti-Ionotropic Glutamate receptor 4 antibody
    See all Ionotropic Glutamate receptor 4 primary antibodies
  • Description
    Rabbit polyclonal to Ionotropic Glutamate receptor 4
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Mouse Ionotropic Glutamate receptor 4 aa 295-325 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: P48058

  • Positive control
    • K562 cell line and Mouse spleen tissue lysates, Human brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab171423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/100 - 1/500. Predicted molecular weight: 101 kDa.

Target

  • Function
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
  • Sequence similarities
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
  • Post-translational
    modifications
    Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • Cellular localization
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AMPA 4 antibody
    • AMPA selective glutamate receptor 4 antibody
    • AMPA-selective glutamate receptor 4 antibody
    • AMPA4 antibody
    • GluA 4 antibody
    • GluA4 antibody
    • GluR 4 antibody
    • GluR D antibody
    • GluR-4 antibody
    • GluR-D antibody
    • GluR4 antibody
    • GLUR4C antibody
    • GLURD antibody
    • Glutamate receptor 4 antibody
    • Glutamate receptor ionotrophic AMPA 4 antibody
    • Glutamate receptor ionotropic antibody
    • GRIA 4 antibody
    • Gria4 antibody
    • GRIA4_HUMAN antibody
    see all

Images

  • Anti-Ionotropic Glutamate receptor 4 antibody (ab171423) at 1/100 dilution + K562 cell line lysate at 35 µg

    Predicted band size: 101 kDa

  • Anti-Ionotropic Glutamate receptor 4 antibody (ab171423) at 1/100 dilution + Mouse spleen tissue lysate at 35 µg

    Predicted band size: 101 kDa

  • Immunohistochemical analysis of paraffin embedded Human brain tissue labeling Glutamate receptor 4 with ab171423 at 1/10 followed by peroxidase conjugation of the secondary antibody and DAB staining.

References

ab171423 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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