Overview

  • Product name

    IOX-1, histone demethylase JMJD inhibitor
  • Description

    Cell permeable histone demethylase JMJD inhibitor
  • Alternative names

    • 5-carboxy-8HQ
  • Biological description

    Cell permeable histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Broad spectrum 2-oxoglutarate oxygenase inhibitor. Inhibits JMJD2A-mediated H3K9me3 demethylation.

  • Purity

    > 99%
  • CAS Number

    5852-78-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8-Hydroxyquinoline-5-carboxylic acid
  • Molecular weight

    189.17
  • Molecular formula

    C10H7NO3
  • PubChem identifier

    459617
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in 2eq. NaOH to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    c1cc2c(ccc(c2nc1)O)C(O)=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • King ON  et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One 5:e15535 (2010). Read more (PubMed: 21124847) »
  • Smith G  et al. One-dimensional hydrogen-bonded structures in the 1:1 proton-transfer compounds of 4,5-dichlorophthalic acid with 8-hydroxyquinoline, 8-aminoquinoline and quinoline-2-carboxylic acid (quinaldic acid). Acta Crystallogr C 64:o180-3 (2008). Read more (PubMed: 18322349) »
  • Warshakoon NC  et al. Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors. Bioorg Med Chem Lett 16:5517-22 (2006). Read more (PubMed: 16931007) »

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