IOX2, HIF-1alpha prolyl hydroxylase-2 (PHD2) inhibitor (ab218604)

Overview

  • Product name

    IOX2, HIF-1alpha prolyl hydroxylase-2 (PHD2) inhibitor
  • Description

    Potent, cell-permeable, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor 
  • Alternative names

    • JICL38
    • N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine
  • Biological description

    Potent, cell-permeable, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.

  • Purity

    > 98%
  • CAS Number

    931398-72-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
  • Molecular weight

    352.34
  • Molecular formula

    C19H16N2O5
  • PubChem identifier

    54685215
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Deppe J  et al. Impairment of hypoxia-induced HIF-1a signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol 90:1141-50 (2016). Read more (PubMed: 26082309) »
  • Chan MC  et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS One 10:e0132004 (2015). Read more (PubMed: 26147748) »
  • Chowdhury R  et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol 8:1488-96 (2013). Read more (PubMed: 23683440) »

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