Overview

  • Product name

    IPA 3, Group I, p21-activated kinase (PAK) inhibitor
  • Description

    Group I, p21-activated kinase (PAK) inhibitor
  • Biological description

    Group I, p21-activated kinase (PAK) inhibitor (IC50 = 2.5 μM). Non-ATP competitive, allosteric inhibition in vivo. Selectivity over >200 other kinases.
  • Purity

    > 97%
  • CAS Number

    42521-82-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ye DZ  et al. p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112. PLoS One 6:e27637 (2011). Read more (PubMed: 22096607) »
  • Viaud J & Peterson JR An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther 8:2559-65 (2009). Read more (PubMed: 19723886) »
  • Deacon SW  et al. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol 15:322-31 (2008). Read more (PubMed: 18420139) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141014.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up