Key features and details
- Rabbit polyclonal to IPL-1/STK13/Aurora C
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-IPL-1/STK13/Aurora C antibody
See all IPL-1/STK13/Aurora C primary antibodies
DescriptionRabbit polyclonal to IPL-1/STK13/Aurora C
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
Synthetic peptide corresponding to Human IPL-1/STK13/Aurora C. (Near the N terminal; NP_001015878).
Database link: Q9UQB9
- Mouse testis, HeLa, Human liver cancer, A375 and 293T lysates; Human brain tissue.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198705 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/200 - 1/1000. Predicted molecular weight: 36 kDa.|
|IHC-P||1/15 - 1/50.|
FunctionMay play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis.
Tissue specificityIsoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
Involvement in diseaseDefects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Contains 1 protein kinase domain.
Cellular localizationChromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis.
- Information by UniProt
- AURKC antibody
- AIE 2 antibody
- Aie1 antibody
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling IPL-1/STK13/Aurora C with ab198705 at 1/15 dilution.
All lanes : Anti-IPL-1/STK13/Aurora C antibody (ab198705) at 1/150 dilution
Lane 1 : Mouse testis tissue lysate
Lane 2 : HeLa cell lysate
Lane 3 : Human liver cancer lysate
Lane 4 : A375 cell lysate
Lane 5 : 293T cell lysate
Lysates/proteins at 40 µg per lane.
Predicted band size: 36 kDa
Exposure time: 1 minute
ab198705 has been referenced in 1 publication.
- Zhou Y et al. Butein suppresses hepatocellular carcinoma growth via modulating Aurora B kinase activity. Int J Biol Sci 14:1521-1534 (2018). PubMed: 30263005