Overview

  • Product name

    Anti-IPL-1/STK13/Aurora C antibody
    See all IPL-1/STK13/Aurora C primary antibodies
  • Description

    Rabbit polyclonal to IPL-1/STK13/Aurora C
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human IPL-1/STK13/Aurora C. (Near the N terminal; NP_001015878).
    Database link: Q9UQB9

  • Positive control

    • Mouse testis, HeLa, Human liver cancer, A375 and 293T lysates; Human brain tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab198705 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/1000. Predicted molecular weight: 36 kDa.
IHC-P 1/15 - 1/50.

Target

  • Function

    May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis.
  • Tissue specificity

    Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
  • Involvement in disease

    Defects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization

    Chromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis.
  • Information by UniProt
  • Database links

  • Alternative names

    • AURKC antibody
    • AIE 2 antibody
    • Aie1 antibody
    • AIE2 antibody
    • AIK 3 antibody
    • AIK3 antibody
    • ARK 3 antibody
    • ARK-3 antibody
    • ARK3 antibody
    • Aur C antibody
    • AurC antibody
    • Aurkc antibody
    • AURKC_HUMAN antibody
    • aurora 3 antibody
    • Aurora C antibody
    • Aurora kinase C antibody
    • aurora related kinase 3 antibody
    • Aurora-related kinase 3 antibody
    • Aurora/Ipl1 related kinase 3 antibody
    • Aurora/Ipl1-related kinase 3 antibody
    • Aurora/Ipl1/Eg2 protein 2 antibody
    • EC 2.7.11.1 antibody
    • Serine threonine protein kinase 13 antibody
    • serine/threonine kinase 13 (aurora/IPL1 like) antibody
    • serine/threonine protein kinase aurora C antibody
    • Serine/threonine-protein kinase 13 antibody
    • Serine/threonine-protein kinase aurora-C antibody
    • SPGF5 antibody
    • STK13 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling IPL-1/STK13/Aurora C with ab198705 at 1/15 dilution.

  • All lanes : Anti-IPL-1/STK13/Aurora C antibody (ab198705) at 1/150 dilution

    Lane 1 : Mouse testis tissue lysate
    Lane 2 : HeLa cell lysate
    Lane 3 : Human liver cancer lysate
    Lane 4 : A375 cell lysate
    Lane 5 : 293T cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 36 kDa


    Exposure time: 1 minute


    10% SDS-PAGE.

References

This product has been referenced in:

  • Zhou Y  et al. Butein suppresses hepatocellular carcinoma growth via modulating Aurora B kinase activity. Int J Biol Sci 14:1521-1534 (2018). Read more (PubMed: 30263005) »
See 1 Publication for this product

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