Overview

  • Product name

    Anti-IPO 38 antibody [IPO38] - Proliferation Marker
    See all IPO 38 primary antibodies
  • Description

    Mouse monoclonal [IPO38] to IPO 38 - Proliferation Marker
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-P, ICC/IF, IHC-Frmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Tissue, cells or virus corresponding to Human IPO 38. Spleen cells of a patient with hairy cell leukemia

  • Positive control

    • Raji and PHA-stimulated (>12 hours) human or mouse lymphocytes. Breast and colorectal carcinomas.
  • General notes

    ab190704 recognizes a protein of 14-16kDa, which is a novel nuclear antigen of proliferating cells. IPO 38 antigen is present in the nuclei of proliferating cells such as Hodgkin’s disease and non-Hodgkin’s lymphomas, different forms of leukemias, breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes. IPO 38 can be a useful marker of cell proliferation during monitoring of tumor progression.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
  • Concentration information loading...
  • Purification notes

    Bioreactor Concentrate
  • Clonality

    Monoclonal
  • Clone number

    IPO38
  • Isotype

    IgM
  • Light chain type

    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab190704 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 0.5 - 1 µg/ml.
IHC-Fr Use at an assay dependent concentration.

Target

  • Relevance

    IPO-38 antigen is present in the nuclei of proliferating cells such as Hodgkin's disease and non-Hodgkin's lymphomas, different forms of leukemias, breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes. IPO-38 can be a useful marker of cell proliferation during monitoring of tumor progression.

References

ab190704 has not yet been referenced specifically in any publications.

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