Overview

  • Product name

    Anti-IPO5 antibody - C-terminal
    See all IPO5 primary antibodies
  • Description

    Rabbit polyclonal to IPO5 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Human, Pig, Xenopus laevis, Chimpanzee
  • Immunogen

    Recombinant fragment within Human IPO5 (C terminal). The exact sequence is proprietary.
    Database link: O00410

  • Positive control

    • IHC-P: Mouse duodenum and pancreas tissues; Rat hind brain tissue.
  • General notes

     This product was previously labelled as Karyopherin beta 3

     

Properties

Applications

Our Abpromise guarantee covers the use of ab228929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.

Target

  • Function

    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
  • Sequence similarities

    Belongs to the importin beta family.
    Contains 6 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • Cellular localization

    Cytoplasm. Nucleus. Nucleus > nucleolus. Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp686O1576 antibody
    • FLJ43041 antibody
    • IMB3 antibody
    • Imp5 antibody
    • Importin 5 antibody
    • Importin beta 3 subunit antibody
    • Importin subunit beta 3 antibody
    • Importin subunit beta-3 antibody
    • Importin-5 antibody
    • IPO 5 antibody
    • IPO5 antibody
    • IPO5_HUMAN antibody
    • Karyopherin beta 3 antibody
    • Karyopherin beta-3 antibody
    • KPNB3 antibody
    • MGC2068 antibody
    • Pse1 antibody
    • Ran binding protein 5 antibody
    • Ran GTP binding protein 5 antibody
    • Ran-binding protein 5 antibody
    • RanBP 5 antibody
    • RanBP5 antibody
    see all

Images

  • Paraffin-embedded mouse duodenum tissue stained for IPO5 using ab228929 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded mouse pancreas tissue stained for IPO5 using ab228929 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded rat hind brain tissue stained for IPO5 using ab228929 at 1/500 dilution in immunohistochemical analysis.

References

ab228929 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab228929.
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