Ipragliflozin, sodium-glucose cotransporter 2 (SGLT2) inhibitor (ab235547)

Overview

  • Product name

    Ipragliflozin, sodium-glucose cotransporter 2 (SGLT2) inhibitor
  • Description

    Potent, selective sodium-glucose cotransporter 2 (SGLT2) inhibitor.
  • Alternative names

    • ASP1941
  • Biological description

    Potent, selective sodium-glucose cotransporter 2 (SGLT2) inhibitor. Increases glucose excretion.

  • Purity

    > 98%
  • General notes

    Protect from air and light.

    DMSO (~30 mg/ml).

  • CAS Number

    761423-87-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
  • Molecular weight

    404.45
  • Molecular formula

    C21H21FO5S
  • PubChem identifier

    10453870
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)C=C(S2)CC3=C(C=CC(=C3)C4C(C(C(C(O4)CO)O)O)O)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Imamura M  et al. Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. Bioorg Med Chem 20:3263-79 (2012). Read more (PubMed: 22507206) »
  • Veltkamp SA  et al. Effect of Ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects. Clin Drug Investig 31:839-51 (2011). Read more (PubMed: 21877761) »

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