Overview

  • Product name

    Ipratropium bromide, mAChR antagonist
  • Description

    Non-selective, potent mAChR antagonist
  • Biological description

    Non-selective, potent mAChR antagonist. Inhibits electrical field stimulation-induced contraction in trachea (IC50 = 0.6 nM). Shows bronchodilatory effects in vivo.
  • Purity

    > 99%
  • CAS Number

    22254-24-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (8-Methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate bromide
  • Molecular weight

    412.36
  • Molecular formula

    C20H30BrNO3
  • PubChem identifier

    31098
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM, in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.[Br-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Blonder JP  et al. Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation. BMC Pulm Med 14:3 (2014). Read more (PubMed: 24405692) »
  • Zhang L  et al. Hippocampal CA field neurogenesis after pilocarpine insult: The hippocampal fissure as a neurogenic niche. J Chem Neuroanat 56:45-57 (2014). Read more (PubMed: 24607693) »
  • Takahashi T  et al. Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am J Respir Crit Care Med 150:1640-5 (1994). Read more (PubMed: 7952627) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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