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    ips1-antibody-ab240581.pdf

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Signal Transduction Signaling Pathway Lipid Signaling Lipid Kinases
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Anti-IPS1 antibody (ab240581)

  • Datasheet
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Western blot - Anti-IPS1 antibody (ab240581)
  • Immunoprecipitation - Anti-IPS1 antibody (ab240581)

Key features and details

  • Rabbit polyclonal to IPS1
  • Suitable for: WB, IP
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-IPS1 antibody
    See all IPS1 primary antibodies
  • Description

    Rabbit polyclonal to IPS1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cow, Orangutan
  • Immunogen

    Synthetic peptide within Human IPS1 aa 1383-1433. The exact sequence is proprietary. (GeneID 9677).
    Database link: Q6PFW1

  • Positive control

    • WB: HeLa, HEK-293T and Jurkat cell lysate. IP: HEK-293T cell lysate.
  • General notes

     This product was previously labelled as HISPPD2A

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7
    Preservative: 0.09% Sodium azide
    Constituent: Tris citrate/phosphate
  • Concentration information loading...
  • Purity

    Affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Signaling Pathway
    • Lipid Signaling
    • Lipid Kinases

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab150035)
    • HeLa whole cell lysate (ab29545)
    • Jurkat whole cell lysate (ab30128)
    • Jurkat whole cell lysate (ab7899)

Applications

Our Abpromise guarantee covers the use of ab240581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000.
IP Use at 2-10 µg/mg of lysate.

Target

  • Relevance

    Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Activated when cells are exposed to hyperosmotic stress.
  • Cellular localization

    Cytoplasm, cytosol and Plasma membrane
  • Database links

    • Entrez Gene: 510684 Cow
    • Entrez Gene: 9677 Human
    • Omim: 610979 Human
    • SwissProt: A7Z050 Cow
    • SwissProt: Q6PFW1 Human
    • SwissProt: Q5RDF1 Orangutan
    • Unigene: 156814 Human
    • Unigene: 679911 Human
    • Alternative names

      • diphosphoinositol pentakisphosphate kinase 1 antibody
      • HISPPD2A antibody
      • histidine acid phosphatase domain containing 2A antibody
      • Histidine acid phosphatase domain-containing protein 2A antibody
      • hsVIP1 antibody
      • Inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinase 1 antibody
      • Inositol pyrophosphate synthase 1 antibody
      • InsP6 and PP IP5 kinase 1 antibody
      • IP6 kinase antibody
      • IP6K antibody
      • IPS1 antibody
      • KIAA0377 antibody
      • PP IP5 kinase 1 antibody
      • PPIP5K1 antibody
      • VIP1 antibody
      see all

    Images

    • Western blot - Anti-IPS1 antibody (ab240581)
      Western blot - Anti-IPS1 antibody (ab240581)
      All lanes : Anti-IPS1 antibody (ab240581) at 1 µg/ml

      Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate
      Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate
      Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Exposure time: 30 seconds


      Detection: Chemiluminescence with an exposure time of 30 seconds.

       

    • Immunoprecipitation - Anti-IPS1 antibody (ab240581)
      Immunoprecipitation - Anti-IPS1 antibody (ab240581)

      IPS1 was immunoprecipitated from HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN lysis buffer, using ab240581 at 6 μg per reaction. For western blotting, ab240581 was used at 0.4 µg/ml.


      Lane 1: ab240581 used for IP at 6 µg per reaction.
      Lane 2: Control IgG.

      Detection: Chemiluminescence with an exposure time of 30 seconds.

       

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab240581? Please let us know so that we can cite the reference in this datasheet.

    ab240581 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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