Overview

  • Product name

    IQDMA, Cell-permeable STAT5 inhibitor
  • Description

    Cell-permeable STAT5 inhibitor
  • Biological description

    Cell-permeable STAT5 inhibitor (IC50 = 8 μM). Indoloquinoline derivative. Antineoplastic agent with broad spectrum antitumor activity seen in vitro. Induces cell-cycle arrest at the G2/M phase.
  • Purity

    > 98%
  • CAS Number

    401463-02-3
  • Chemical structure

    Chemical Structure

Properties

Associated products

References

This product has been referenced in:

  • Su JC  et al. Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sci 85:505-16 (2009). Read more (PubMed: 19699753) »
  • Chien CM  et al. Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells. Chem Biol Interact 176:40-7 (2008). Read more (PubMed: 18638462) »
  • Yang SH  et al. Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells. Leuk Res 31:1413-20 (2007). Read more (PubMed: 17397922) »
  • Hu XW  et al. A novel indoloquinoline derivative, IQDMA, induces S-phase arrest and apoptosis in promyelocytic leukemia HL-60 cells. Cell Biol Toxicol 22:417-27 (2006). Read more (PubMed: 16906476) »
See 1 Publication for this product

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