Overview

  • Product name

  • Description

    Rabbit polyclonal to IRF2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide within Human IRF2 aa 100-150 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: P14316

  • Positive control

    • IHC-P: Human laryngocarcinoma tissue. Mouse intestine tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab217349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Function

    Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
  • Tissue specificity

    Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
  • Sequence similarities

    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Post-translational
    modifications

    Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
    The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation by SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp686F0244 antibody
    • Interferon regulatory factor 2 antibody
    • IRF 2 antibody
    • IRF-2 antibody
    • IRF2 antibody
    • IRF2_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded human laryngocarcinoma tissue sections labeling IRF2 with ab217349 at a 1/200 dilution. DAB staining.

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded mouse intestine tissue sections labeling IRF2 with ab217349 at a 1/200 dilution. DAB staining.

References

ab217349 has not yet been referenced specifically in any publications.

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