Key features and details
- Rabbit polyclonal to IRF7
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-IRF7 antibody
See all IRF7 primary antibodies
DescriptionRabbit polyclonal to IRF7
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide conjugated to KLH, corresponding to 14 amino acids near the center of Human IRF7.
- Human Spleen tissue
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
- Epigenetics and Nuclear Signaling
- Domain Families
- HLH / Leucine Zipper
- Epigenetics and Nuclear Signaling
- Polymerase associated factors
- Pol II Transcription
Our Abpromise guarantee covers the use of ab115352 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionTranscriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.
Tissue specificityExpressed predominantly in spleen, thymus and peripheral blood leukocytes.
Sequence similaritiesBelongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
modificationsIn response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.
TRAF6-mediated ubiquitination is required for IRF7 activation.
Cellular localizationNucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
- Information by UniProt
- IMD39 antibody
- Interferon regulatory factor 7 antibody
- Interferon regulatory factor 7H antibody
ab115352 has been referenced in 2 publications.
- Wang Y et al. Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-a signaling participate in pathogenesis of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol 125:459-467.e2 (2018). IHC-P . PubMed: 29429903
- Hirashima K et al. Telomere length influences cancer cell differentiation in vivo. Mol Cell Biol 33:2988-95 (2013). ICC/IF . PubMed: 23716593