Overview

  • Product name

  • Description

    Rabbit polyclonal to IRF7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Recombinant fragment within Human IRF7 (internal sequence). The exact sequence is proprietary.
    Database link: Q92985

  • Positive control

    • WB: Jurkat, Raji and NCI-H929 whole cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab226836 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000.

Target

  • Function

    Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.
  • Tissue specificity

    Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
  • Sequence similarities

    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Post-translational
    modifications

    In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.
    TRAF6-mediated ubiquitination is required for IRF7 activation.
  • Cellular localization

    Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • IMD39 antibody
    • Interferon regulatory factor 7 antibody
    • Interferon regulatory factor 7H antibody
    • IRF 7 antibody
    • IRF 7A antibody
    • IRF 7H antibody
    • IRF-7 antibody
    • IRF7 antibody
    • IRF7_HUMAN antibody
    • IRF7A antibody
    • IRF7B antibody
    • IRF7C antibody
    • IRF7H antibody
    see all

Images

  • All lanes : Anti-IRF7 antibody (ab226836) at 1/1000 dilution

    Lane 1 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell extract
    Lane 2 : Raji (human Burkitt's lymphoma cell line) whole cell extract
    Lane 3 : NCI-H929 whole cell extract

    Lysates/proteins at 30 µg per lane.

    Secondary
    All lanes : HRP-conjugated anti-rabbit IgG


    7.5% SDS-PAGE gel.

References

ab226836 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab226836.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up