Product nameIRS1 peptide
See all IRS1 proteins and peptides
Amino acids979 to 989
- Recombinant human LOK protein (ab55710)
- Recombinant human Serine/threonine-protein kinase 4/MST-1 (ab60337)
- Recombinant human Axl protein (ab64298)
- Recombinant human IRR protein (ab69988)
- Recombinant human RON protein (ab70541)
- Recombinant human Insulin Receptor protein (Active) (ab70687)
- Recombinant human Dystrophia myotonica protein kinase / DMPK (ab85755)
Our Abpromise guarantee covers the use of ab204853 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ab204853 (IRS1 peptide) can be utilized as a substrate for the following active protein kinases:
ab64298 (Active human Axl protein fragment)
ab85755 (Active human Dystrophia myotonica protein kinase full length protein)
ab69988 (Active Insulin Receptor R protein fragment)
ab70687 (Active human Insulin Receptor protein fragment)
ab70541 (Active human RON protein fragment)
ab60337 (Active human Serine/threonine-protein kinase 4 full length protein)
ab55710 (Active human LOK protein fragment)
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
ReconstitutionDilute peptide in distilled water to a final concentration of 1mg/ml
- HIRS 1
- Insulin receptor substrate 1
FunctionMay mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Involvement in diseasePolymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
Sequence similaritiesContains 1 IRS-type PTB domain.
Contains 1 PH domain.
modificationsSerine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab204853 has not yet been referenced specifically in any publications.