Product nameIRS1 peptide
See all IRS1 proteins and peptides
Amino acids979 to 989
- Recombinant human LOK protein (ab55710)
- Recombinant human Serine/threonine-protein kinase 4/MST-1 (ab60337)
- Recombinant human Axl protein (ab64298)
- Recombinant human IRR protein (ab69988)
- Recombinant human RON protein (ab70541)
- Recombinant human Insulin Receptor protein (Active) (ab70687)
- Recombinant human Dystrophia myotonica protein kinase / DMPK (ab85755)
Our Abpromise guarantee covers the use of ab204853 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ab204853 (IRS1 peptide) can be utilized as a substrate for the following active protein kinases:
ab64298 (Active human Axl protein fragment)
ab85755 (Active human Dystrophia myotonica protein kinase full length protein)
ab69988 (Active Insulin Receptor R protein fragment)
ab70687 (Active human Insulin Receptor protein fragment)
ab70541 (Active human RON protein fragment)
ab60337 (Active human Serine/threonine-protein kinase 4 full length protein)
ab55710 (Active human LOK protein fragment)
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
ReconstitutionDilute peptide in distilled water to a final concentration of 1mg/ml
- HIRS 1
- Insulin receptor substrate 1
FunctionMay mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Involvement in diseasePolymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
Sequence similaritiesContains 1 IRS-type PTB domain.
Contains 1 PH domain.
modificationsSerine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding.
- Information by UniProt
ab204853 has not yet been referenced specifically in any publications.