IRS1 peptide (ab204862)
Key features and details
- Purity: > 95% HPLC
- Suitable for: Functional Studies, HPLC
Description
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Product name
IRS1 peptide
See all IRS1 proteins and peptides -
Purity
> 95 % HPLC. -
Animal free
No -
Nature
Synthetic -
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Sequence
KKKSPGEYVNIEFG -
Amino acids
891 to 902
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Associated products
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Recombinant Protein
Specifications
Our Abpromise guarantee covers the use of ab204862 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Functional Studies
HPLC
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Form
Lyophilized -
Additional notes
ab204862 (IRS1 peptide) can be utilized as a substrate for the following active protein kinases:
ab187246 (Active human ALK protein fragment)
ab84771 (Active human VEGF Receptor 1 full length protein)
ab71657 (Active IGF1 Receptor protein fragment)
ab84791 (Active human Ret protein fragment)
ab125624 (Active human ROS protein fragment) -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
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ReconstitutionDilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.
General Info
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Alternative names
- HIRS 1
- HIRS1
- Insulin receptor substrate 1
see all -
Function
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. -
Involvement in disease
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. -
Sequence similarities
Contains 1 IRS-type PTB domain.
Contains 1 PH domain. -
Post-translational
modificationsSerine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab204862 has not yet been referenced specifically in any publications.