Description

Specifications

Our Abpromise guarantee covers the use of ab204862 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    HPLC

  • Form

    Lyophilised
  • Additional notes

    ab204862 (IRS1 peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab187246 (Active human ALK protein fragment)
    ab84771 (Active human VEGF Receptor 1 full length protein)
    ab71657 (Active IGF1 Receptor protein fragment)
    ab84791 (Active human Ret protein fragment)
    ab125624 (Active human ROS protein fragment)

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

General Info

  • Alternative names

    • HIRS 1
    • HIRS1
    • Insulin receptor substrate 1
    • IRS 1
    • IRS-1
    • IRS1
    • IRS1_HUMAN
    • OTTHUMP00000164234
    see all
  • Function

    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
  • Involvement in disease

    Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
  • Sequence similarities

    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • Post-translational
    modifications

    Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt

References

ab204862 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab204862.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up