Product nameIRS1 (phospho Y896) peptide
See all IRS1 proteins and peptides
Our Abpromise guarantee covers the use of ab5224 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesPositive (ab5224P) and negative (ab5224N) control peptides for the IRS 1 Receptor phospho tyrosine 896 rabbit polyclonal antibody ab4873. Molecular Weight: ab5224P - 1718 ab5224N - 1638 Peptide Content: 80 ± 4% Quantity: 100ug of each peptide.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituent: 0.1% Trifluoroacetic acid
- HIRS 1
- Insulin receptor substrate 1
FunctionMay mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Involvement in diseasePolymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
Sequence similaritiesContains 1 IRS-type PTB domain.
Contains 1 PH domain.
modificationsSerine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding.
- Information by UniProt
ab5224 has not yet been referenced specifically in any publications.