Overview

  • Product name

    ISCK03, SCF/c-Kit inhibitor
  • Description

    Cell-permeable, selective SCF/c-Kit inhibitor
  • Biological description

    Cell-permeable, selective SCF/c-Kit inhibitor (IC50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo.
  • Purity

    > 99%
  • CAS Number

    945526-43-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Liang J  et al. The C-kit receptor-mediated signal transduction and tumor-related diseases. Int J Biol Sci 9:435-43 (2013). Read more (PubMed: 23678293) »
  • Kamlah F  et al. Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells. Int J Radiat Oncol Biol Phys 80:1541-9 (2011). Read more (PubMed: 21621345) »
  • Na YJ  et al. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. Biochem Pharmacol 74:780-6 (2007). Read more (PubMed: 17658483) »

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