Product nameIsobarbituric acid, Uracil derative
Description5-hydroxy derivative of the nucleobase Uracil (ab143729) and an isomer of Barbituric Acid. Oxidative DNA damage biomarker.
- NSC 95958
5-hydroxy derivative of the nucleobase Uracil (ab143729) and an isomer of Barbituric Acid. Studies show that it can form stable base pairs with all four bases in a DNA duplex. Used as an oxidative DNA damage biomarker.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewDMSO (Sparingly)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Takezawa Y et al. Bifacial Base-Pairing Behaviors of 5-Hydroxyuracil DNA Bases through Hydrogen Bonding and Metal Coordination. Chemistry 21:14713-6 (2015). Read more (PubMed: 26332356) »
- Thiviyanathan V et al. 5-hydroxyuracil can form stable base pairs with all four bases in a DNA duplex. Chem Commun (Camb) N/A:400-2 (2005). Read more (PubMed: 15645051) »
- Jenner A et al. Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases. Biochem J 331 ( Pt 2):365-9 (1998). Read more (PubMed: 9531471) »