Isobarbituric acid, Uracil derative (ab145012)

Overview

  • Product name

    Isobarbituric acid, Uracil derative
  • Description

    5-hydroxy derivative of the nucleobase Uracil (ab143729) and an isomer of Barbituric Acid. Oxidative DNA damage biomarker.
  • Alternative names

    • 2,4,5-Trihydroxypyrimidine
    • 5-Hydroxyuracil
    • Dihydro-2,4,5(3H)-pyrimidinetrione
    • NSC 95958
  • Biological description

    5-hydroxy derivative of the nucleobase Uracil (ab143729) and an isomer of Barbituric Acid. Studies show that it can form stable base pairs with all four bases in a DNA duplex. Used as an oxidative DNA damage biomarker.

  • CAS Number

    496-76-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,4,5-Trihydroxypyrimidine
  • Molecular weight

    128.09
  • Molecular formula

    C4H4N2O3
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    DMSO (Sparingly)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Takezawa Y  et al. Bifacial Base-Pairing Behaviors of 5-Hydroxyuracil DNA Bases through Hydrogen Bonding and Metal Coordination. Chemistry 21:14713-6 (2015). Read more (PubMed: 26332356) »
  • Thiviyanathan V  et al. 5-hydroxyuracil can form stable base pairs with all four bases in a DNA duplex. Chem Commun (Camb) N/A:400-2 (2005). Read more (PubMed: 15645051) »
  • Jenner A  et al. Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases. Biochem J 331 ( Pt 2):365-9 (1998). Read more (PubMed: 9531471) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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