Isoimperatorin, COX-dependent PGD2 production inhibitor (ab143499)

Overview

  • Product name

    Isoimperatorin, COX-dependent PGD2 production inhibitor
  • Description

    Inhibits COX-dependent PGD2 production
  • Biological description

    Inhibits COX-dependent PGD2 production (IC50 values are 11 and 24 μM for COX-1 and COX-2 respectively). Inhibits LTC4 production (IC50 = 6 μM). Shows antiproliferative effects. Shows vasodilatory and anti-inflammatory effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    482-45-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-(3-Methylbut-2-enoxy)furo[3,2-g]chromen-7-one
  • Molecular weight

    270.28
  • Molecular formula

    C16H14O4
  • PubChem identifier

    68081
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Nie H  et al. Imperatorin is responsible for the vasodilatation activity of Angelica Dahurica var. Formosana regulated by nitric oxide in an endothelium-dependent manner. Chin J Integr Med 15:442-7 (2009). Read more (PubMed: 20082250) »
  • Moon TC  et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res 31:210-5 (2008). Read more (PubMed: 18365692) »
  • Kang OH  et al. Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages. Pharmacol Res 55:263-70 (2007). Read more (PubMed: 17229575) »

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