Isoorientin, Cyclooxygenase-2 inhibitor (ab145014)

Overview

  • Product name

    Isoorientin, Cyclooxygenase-2 inhibitor
  • Description

    Selective Cyclooxygenase-2 (COX-2) inhibitor.
  • Alternative names

    • Homoorientin
    • Lespecapitioside
    • Lespecapitoside
    • Luteolin 6-C-glucoside
    • Lutonaretin
    see all
  • Biological description

    C-glycosyl flavone that can be isolated from the passion flower, and several other species of plants. Has anti-inflammatory, antimicrobial and antioxidant properties. Selective Cyclooxygenase-2 (COX-2) inhibitor.

  • CAS Number

    4261-42-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(3,4-Dihydroxyphenyl)-6-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
  • Molecular weight

    448.38
  • Molecular formula

    C21H20O11
  • Storage instructions

    Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Lin X  et al. Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway. J Ethnopharmacol 187:187-94 (2016). Read more (PubMed: 27130644) »
  • Yuan L  et al. Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines. Biomed Pharmacother 81:356-62 (2016). Read more (PubMed: 27261613) »
  • Sumalatha M  et al. Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. Nat Prod Commun 10:1703-4 (2015). Read more (PubMed: 26669106) »

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