Overview

  • Product name

    Isorhamnetin, Antioxidant agent
  • Description

    Antioxidant agent
  • Biological description

    Antioxidant agent. Inhibts iNOS protein and mRNA expression. Inhibits NO production (IC50 = 30 μM). Shows anti-inflammatory and antiproliferative effects. Active in vivo. Orally active. Metabolite of Quercetin (Asc 247).
  • Purity

    > 98%
  • CAS Number

    480-19-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
  • Molecular weight

    316.26
  • Molecular formula

    C16H12O7
  • PubChem identifier

    5281654
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ramachandran L  et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor ? activation pathway in gastric cancer. J Biol Chem 287:38028-40 (2012). Read more (PubMed: 22992727) »
  • Boesch-Saadatmandi C  et al. Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155. J Nutr Biochem 22:293-9 (2011). Read more (PubMed: 20579867) »
  • Hämäläinen M  et al. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm 2007:45673 (2007). Read more (PubMed: 18274639) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142622.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up