Overview

  • Product name

    Isoxanthohumol, Phytoestrogen
  • Description

    Phytoestrogen
  • Biological description

    Phytoestrogen. Induces apoptosis. Induces G2/M cell cycle arrest. Shows antitumor effects. Shows weakly estrogenic effects in vivo. Orally active.
  • CAS Number

    70872-29-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
  • Molecular weight

    354.40
  • Molecular formula

    C21H22O5
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=CCC1=C(C=C(C2=C1OC(CC2=O)C3=CC=C(C=C3)O)OC)O)C
  • Source

    Humulus lupulus

  • Research areas

References

This product has been referenced in:

  • Kiyofuji A  et al. Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes. J Oleo Sci 63:593-7 (2014). Read more (PubMed: 24829131) »
  • Overk CR  et al. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chem Biol Interact 176:30-9 (2008). Read more (PubMed: 18619951) »
  • Allsopp P  et al. A comparison of the anticancer properties of isoxanthohumol and 8-prenylnaringenin using in vitro models of colon cancer. Biofactors 39:441-7 (0). Read more (PubMed: 23361834) »

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